Immunity, Tumors and Aging: The Role of HSP70

1. Front Matter

   Pages i-xi

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2. A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle

   • Igor Malyshev

   Pages 1-13

3. The Functions of HSP70 in Normal Cells

   • Igor Malyshev

   Pages 15-29

4. HSP70 in Damaged Cells

   • Igor Malyshev

   Pages 31-45

5. Mechanisms of Activation and Inactivation of HSP70 Synthesis

   • Igor Malyshev

   Pages 47-61

6. HSP70 in the Immune Responses

   • Igor Malyshev

   Pages 63-82

7. HSP70 in Carcinogenesis

   • Igor Malyshev

   Pages 83-98

8. HSP70 in Aging

   • Igor Malyshev

   Pages 99-111

9. The Role of HSP70 in the Protection of: (A) The Brain in Alzheimer’s Disease and (B) The Heart in Cardiac Surgery

   • Igor Malyshev

   Pages 113-139

10. Back Matter

    Pages 141-141

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The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiac surgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.

• Age-related Diseases
• Cardiovascular
• Heat Shock Proteins
• Immunology
• Tumors

• Medicine and Dentistry, Department of Pathophysiology, Moscow State University of, Moscow, Russia

  Igor Malyshev

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