Phosphoinositides and Disease

1. Front Matter

   Pages i-vi

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2. An Introduction to Phosphoinositides

   • Tania Maffucci

   Pages 1-42

3. Phosphoinositides and Cardiovascular Diseases

   • Alessandra Ghigo, Alessia Perino, Emilio Hirsch

   Pages 43-60

4. Phosphoinositides in Insulin Action and Diabetes

   • Dave Bridges, Alan R. Saltiel

   Pages 61-85

5. Phosphoinositides in Neuroexocytosis and Neuronal Diseases

   • Peter J. Wen, Shona L. Osborne, Frederic A. Meunier

   Pages 87-98

6. Effects of Phosphoinositides and Their Derivatives on Membrane Morphology and Function

   • Banafshé Larijani, Dominic L. Poccia

   Pages 99-110

7. Molecular Analysis of Protein–Phosphoinositide Interactions

   • Tatiana G. Kutateladze

   Pages 111-126

8. PIKfyve and its Lipid Products in Health and in Sickness

   • Assia Shisheva

   Pages 127-162

9. Class I Phosphoinositide 3-Kinases in Normal and Pathologic Hematopoietic Cells

   • François Vergez, Christian Recher, Bernard Payrastre

   Pages 163-184

10. The Diverse Functions of Phosphatidylinositol Transfer Proteins

    • Shamshad Cockcroft

    Pages 185-208

11. Myotubularin Phosphoinositide Phosphatases in Human Diseases

    • Leonela Amoasii, Karim Hnia, Jocelyn Laporte

    Pages 209-233

12. Nuclear PI-PLC β1 and Myelodysplastic Syndromes: From Bench to Clinics

    • Sara Mongiorgi, Matilde Y. Follo, Cristina Clissa, Roberto Giardino, Milena Fini, Lucia Manzoli et al.

    Pages 235-245

13. Inositol Polyphosphate Phosphatases in Human Disease

    • Sandra Hakim, Micka C. Bertucci, Sarah E. Conduit, David L. Vuong, Christina A. Mitchell

    Pages 247-314

14. Back Matter

    Pages 315-318

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Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLCpathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

• Inositol Phosphates
• Phosphoinositides

• CTR DIABETES BARTS, Queen Mary University of London, UK, LONDON E1 2AT, United Kingdom

  MARCO FALASCA

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