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Morphofunctional Aspects of Tumor Microcirculation

  • Book
  • © 2012

Overview

Authors:
  1. Domenico Ribatti

    1. Policlinico, Department of Human Anatomy, University of Bari Medical School, Bari, Italy

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  • Tumors depend on a vascular supply for their growth
  • Tumor vasculature is clearly different to normal vasculature
  • The phenotypic range of tumor endothelium is influenced by the specific tumor microenvironment and by epigenetic effects
  • Two approaches are available for targeting tumor vasculature: a) prevent new blood vessel formation; b) disrupt tumor vasculature

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Table of contents (4 chapters)

  1. Front Matter

    Pages 1-1
    Download chapter PDF

  2. Introduction

    • Domenico Ribatti
    Pages 1-3

  3. Morphological Aspects of Tumor Vasculature

    • Domenico Ribatti
    Pages 5-19

  4. Mechanisms of Control of Angiogenesis in Tumor Vasculature

    • Domenico Ribatti
    Pages 21-51

  5. Anti-Angiogenesis and Vascular Targeting in Tumor Vasculature

    • Domenico Ribatti
    Pages 53-82

  6. Back Matter

    Pages 6-6
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Keywords

About this book

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

Authors and Affiliations

  • Policlinico, Department of Human Anatomy, University of Bari Medical School, Bari, Italy

    Domenico Ribatti

Bibliographic Information

  • Book Title: Morphofunctional Aspects of Tumor Microcirculation

  • Authors: Domenico Ribatti

  • DOI: https://doi.org/10.1007/978-94-007-4936-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2012

  • Hardcover ISBN: 978-94-007-4935-1Published: 29 September 2012

  • Softcover ISBN: 978-94-017-8204-3Published: 15 October 2014

  • eBook ISBN: 978-94-007-4936-8Published: 28 September 2012

  • Edition Number: 1

  • Number of Pages: XII, 116

  • Topics: Cancer Research, Oncology, Cell Biology

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