Novel Apoptotic Regulators in Carcinogenesis

1. Front Matter

   Pages i-xi

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2. Apoptosis Inducer from Streblus asper Extracts for Cancer Chemoprevention

   • Azman Seeni, Nur Ayunie Zulkepli, Ridhwan Abdul Wahab

   Pages 1-25

3. Apoptosis Induction by Nimbolide, a Limonoid from Azadirachta indica: Molecular Targets and Signaling Networks

   • Nagini Siddavaram, Vidya Priyadarsini Ramamurthi

   Pages 27-43

4. Heterocyclics as Inducers of Apoptosis

   • Ahmed Kamal, Adla Mallareddy, Paidakula Suresh

   Pages 45-92

5. Anthocyanins as Apoptotic Regulators

   • Jairam Vanamala, Sridhar Radhakrishnan, Lavanya Reddivari, Aaron Massey

   Pages 93-122

6. Apoptosis as a Mechanism Involved in the Anticancer Effect of Dietary n-3 Polyunsaturated Fatty Acids

   • Simona Serini, Elena Fasano, Elisabetta Piccioni, Achille Renato Maria Cittadini, Gabriella Calviello

   Pages 123-147

7. Apoptotic Pathways upon Arsenite Treatment

   • Dongyun Zhang, Chuanshu Huang

   Pages 149-187

8. Flavokawains in Cancer Prevention and Treatment: Potentials and Challenges

   • Danielle D. Jandial, Anne R. Simoneau, Xiaolin Zi

   Pages 189-204

9. Progesterone Receptor Modulators Induce Apoptosis in Mammary Tumors and Uterine Leiomyomas

   • Konstantin Christov, Ronald D. Wiehle

   Pages 205-226

10. Apoptotic Regulators and Its Clinical Implications in Mammary Carcinoma

    • Subhadeep Das, Malay Chatterjee

    Pages 227-245

11. Curcumin Analogs as Inhibitors of the Jak-STAT Signal Transduction Pathway

    • Jennifer Yang, Gregory B. Lesinski

    Pages 247-266

12. Targeting Cancer by Betulin and Betulinic Acid

    • René Csuk

    Pages 267-287

13. Back Matter

    Pages 289-299

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Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.

• Apoptosis
• Cancer treatment
• Carcinogenesis
• Novel agents
• Entomology

From the reviews:

“This book is appropriate for scientific professionals in the field of basic cancer research, drug development, and cancer medicine, as well as professionals in the pharmaceutical and pharmacological industries. … This book provides well-summarized information on interesting anticancer agents which have been substantially studied recently on their ability to induce apoptosis in cancer cells. … The book is a good source of information for the scientific community and medicinal industries who are interested in development of anticancer drugs.” (Qi Chen, Doody’s Review Service, January, 2013)

• , Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR

  George G. Chen, Paul B.S. Lai

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