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DNA Repair of Cancer Stem Cells

  • Book
  • © 2013

Overview

Editors:
  1. Lesley A Mathews

    1. Division of Pre-Clinical Innovation, Nat. Center for Advancing Transl. Scie, National Institutes of Health, Rockville, USA

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  2. Stephanie M Cabarcas

    1. Gannon University, Erie, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Elaine M. Hurt

    1. Preclinical Oncology Research, Gaithersburg, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Currently there are no books solely available on DNA repair mechanisms and Cancer Stem Cells
  • This information can be used by academic institutions, pharmaceutical companies, medical professionals, government and biotechnology companies to aid in the drug discovery process against cancer stem cells
  • Experts in the fields of stem cells, cancer biology and DNA repair have come together to share their cutting edge knowledge on how to design drugs against these drug resistant cells Included is a chapter on how to screen for drugs to kill Cancer Stem Cells and attack their efficient DNA repair mechanisms
  • Wonderful text to teach from for an upper level college or graduate level classes on rational drug design
  • Includes supplementary material: sn.pub/extras

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Table of contents (10 chapters)

  1. Front Matter

    Pages 1-1
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  2. Introduction to Cancer Stem Cells

    • Chengzhuo Gao, Robert E. Hollingsworth, Elaine M. Hurt
    Pages 1-18

  3. DNA Repair Pathways and Mechanisms

    • Thomas S. Dexheimer
    Pages 19-32

  4. Resistance and DNA Repair Mechanisms of Cancer Stem Cells: Potential Molecular Targets for Therapy

    • Aamir Ahmad, Yiwei Li, Bin Bao, Fazlul H. Sarkar
    Pages 33-52

  5. DNA Repair in Normal Stem Cells

    • Olga Momčilović, Gerald Schatten
    Pages 53-87

  6. DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells

    • Monica Venere, Jeremy N. Rich, Shideng Bao
    Pages 89-103

  7. DNA Repair Mechanisms in Breast Cancer Stem Cells

    • Hong Yin, Jonathan Glass
    Pages 105-124

  8. DNA Repair Mechanisms in Other Cancer Stem Cell Models

    • Mihoko Kai
    Pages 125-139

  9. Pancreatic Cancer Stem Cells in Tumor Progression, Metastasis, Epithelial-Mesenchymal Transition and DNA Repair

    • Nagaraj S. Nagathihalli, Erika T. Brown
    Pages 141-155

  10. Targeting Cancer Stem Cell Efficient DNA Repair Pathways: Screening for New Therapeutics

    • Lesley A. Mathews, Francesco Crea, Marc Ferrer
    Pages 157-172

  11. The Future of DNA Repair and Cancer Stem Cells

    • Stephanie M. Cabarcas
    Pages 173-175

  12. Back Matter

    Pages 173-173
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Keywords

About this book

The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.

Editors and Affiliations

  • Division of Pre-Clinical Innovation, Nat. Center for Advancing Transl. Scie, National Institutes of Health, Rockville, USA

    Lesley A Mathews

  • Gannon University, Erie, USA

    Stephanie M Cabarcas

  • Preclinical Oncology Research, Gaithersburg, USA

    Elaine M. Hurt

Bibliographic Information

  • Book Title: DNA Repair of Cancer Stem Cells

  • Editors: Lesley A Mathews, Stephanie M Cabarcas, Elaine M. Hurt

  • DOI: https://doi.org/10.1007/978-94-007-4590-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2013

  • Hardcover ISBN: 978-94-007-4589-6Published: 27 July 2012

  • Softcover ISBN: 978-94-007-9705-5Published: 09 August 2014

  • eBook ISBN: 978-94-007-4590-2Published: 26 July 2012

  • Edition Number: 1

  • Number of Pages: VIII, 180

  • Topics: Biomedicine general, Molecular Medicine, Cancer Research, Stem Cells

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