Endoplasmic Reticulum Stress in Health and Disease

1. Front Matter

   Pages 1-1

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2. Cellular Responses to ER Stress

   1. Front Matter

      Pages 1-1

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   2. Biology of the Endoplasmic Reticulum

      • Sandra JM Healy, Tom Verfaillie, Richard Jäger, Patrizia Agostinis, Afshin Samali

      Pages 3-22

   3. A Tight-Knit Group: Protein Glycosylation, Endoplasmic Reticulum Stress and the Unfolded Protein Response

      • Jared Q Gerlach, Shashank Sharma, Kirk J Leister, Lokesh Joshi

      Pages 23-39

   4. ER Stress Signaling Pathways in Cell Survival and Death

      • Tom Verfaillie, Richard Jäger, Afshin Samali, Patrizia Agostinis

      Pages 41-73

   5. Endoplasmic Reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspection

      • Riccardo Filadi, Enrico Zampese, Tullio Pozzan, Paola Pizzo, Cristina Fasolato

      Pages 75-106

   6. ER Stress and UPR Through Dysregulated ER Ca2+ Homeostasis and Signaling

      • Tim Vervliet, Santeri Kiviluoto, Geert Bultynck

      Pages 107-142

   7. Regulation of ER Stress Responses by microRNAs

      • Danielle E. Read, Ananya Gupta, Karen Cawley, Sanjeev Gupta

      Pages 143-161

   8. ER Stress As Modulator of Autophagy Pathways

      • María Salazar, Sonia Hernández-Tiedra, Mar Lorente, Guillermo Velasco

      Pages 163-184

   9. Physiological ER Stress: The Model of Insulin-Secreting Pancreatic b-Cells

      • Mohammed Bensellam, Patrick Gilon, Jean-Christophe Jonas

      Pages 185-211

3. ER stress in physiological & pathological conditions

   1. Front Matter

      Pages 205-205

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   2. Pathological ER Stress in β Cells

      • Fumihiko Urano, Bryan O’Sullivan-Murphy

      Pages 215-230

   3. Endoplasmic Reticulum Stress and the Unfolded Protein Response in Lipid Metabolism and Obesity

      • Sana Basseri, Richard C. Austin

      Pages 231-256

   4. ER Stress and Inflammation

      • Abhishek D. Garg, Agnieszka Kaczmarek, Dmitri V. Krysko, Peter Vandenabeele

      Pages 257-279

   5. ER Stress in Intestinal Inflammatory Disease

      • Michal F. Tomczak, Arthur Kaser, Richard S. Blumberg

      Pages 281-298

   6. Role of ER Stress in Dysfunction of the Nervous System

      • Kohsuke Kanekura, Simin Lu, Kathryn L. Lipson, Fumihiko Urano

      Pages 299-321

   7. Endoplasmic Reticulum (ER) Stress in Amyotrophic Lateral Sclerosis (ALS)

      • Han-Jou Chen, Jackie de Belleroche

      Pages 323-337

   8. Cardiovascular Disease and Endoplasmic Reticulum Stress

      • Jody Groenendyk, Marek Michalak

      Pages 339-355

   9. Signaling the Unfolded Protein Response in cancer

      • Stéphanie Lhomond, Eric Chevet

      Pages 357-382

   10. UPR Activation in Cancer Cells: A Double-Edged Sword

       • Ethel R. Pereira, Amanda M. Preston, Linda M. Hendershot

       Pages 383-412

The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.

• Cell Death
• Diseases
• ER stress
• Inflammation
• Unfolded Protein response
• Apoptosis

• Dept Molec Cell Bio, K.U. Leuven, B-3000 Leuven, Belgium

  Patrizia Agostinis

• School of Natural Science, Department of Biochemistry, NUI Galway, Galway, Ireland

  Samali Afshin

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