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Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis

  • Book
  • © 2012

Overview

Editors:
  1. György Berencsi III

    1. , Division of Virology, National Center for Epidemiology, Budapest, Hungary

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  • Bidirectional maternal-fetal transport during pregnancy and long-term survival of cells
  • Fetal illnesses caused by receptor mediated maternal-fetal transport of autoimmune IgG
  • Receptor mediated transport of maternal anti-idiotypes may induce fetal TREG cells and fetal IgM
  • Biological therapy of malignancies of pregnants (monoclonal abs) may cause fetal impairment
  • Virus transport to the fetal body might result in later impairment of tumour defence mechanisms

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
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  2. Barriers of the Human Organism and Their Achilles’ Heels

    • György Berencsi III, Maria Takács
    Pages 1-50

  3. Recent Results on the Development of Fetal Immune System: Self, Epigenetic Regulation, Fetal Immune Responses

    • Eva Ay, Krisztina Buzas, Ferenc Banati, Janos Minarovits
    Pages 51-82

  4. The Role of Endogenous Retroviruses in the Formation of Syncytiotrophoblast and Materno-Fetal Barrier

    • Eva Ay, Ferenc Banati, Katalin Turi-Balog, Janos Minarovits
    Pages 83-104

  5. Maternal-Fetal Infections with Human Viruses

    • György Berencsi III, Márta Csire
    Pages 105-169

  6. The Mechanism and Significance of Integration and Vertical Transmission of Human Herpesvirus 6 Genome

    • Jesse H. Arbuckle, Shara Pantry, Peter G. Medveczky
    Pages 171-194

  7. Maternal-Fetal Transmission of HBV

    • Purnima Bhat
    Pages 195-222

  8. Polarised Transfer of Proteins Through the Syncytiotrophobalst and Tissue Culture Cell Lines

    • György Berencsi III, Katalin Ördög
    Pages 223-247

  9. Function of Maternal Idiotypic and Anti-idiotypic Antibodies as Transgenerational Messengers

    • Hilmar Lemke, Radu I. Tanasa, Ahmad Trad, Hans Lange
    Pages 249-279

  10. Fetal and Neonatal Illnesses Caused or Influenced by Maternal Transplacental IgG and/or Therapeutic Antibodies Applied During Pregnancy

    • György Berencsi III, Katalin N. Szomor
    Pages 281-333

  11. Maternal-Fetal Microchimerism and Fetal-Juvenile Malignancies

    • György Berencsi III, Erzsébet Barcsay
    Pages 335-388

  12. Maternal Tumours Associated with and Influenced by Pregnancy

    • György Berencsi III
    Pages 389-441

  13. Back Matter

    Pages 443-464
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Keywords

About this book

The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

Reviews

From the reviews:

“This volume written by virology experts reviews in addition to the maternal-fetal interaction of human viruses, with emphasis on those which influence the development and tumorigenesis in the fetus and neonate. Of interest to virologists, obstetricians, neonatologists, immunologists and oncologists. A timely text.” (Pediatric Endocrinology Reviews (PER), Vol. 10 (2), January, 2013)

Editors and Affiliations

  • , Division of Virology, National Center for Epidemiology, Budapest, Hungary

    György Berencsi III

Bibliographic Information

  • Book Title: Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis

  • Editors: György Berencsi III

  • DOI: https://doi.org/10.1007/978-94-007-4216-1

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2012

  • Hardcover ISBN: 978-94-007-4215-4Published: 07 April 2012

  • Softcover ISBN: 978-94-017-8249-4Published: 09 May 2014

  • eBook ISBN: 978-94-007-4216-1Published: 05 April 2012

  • Edition Number: 1

  • Number of Pages: VIII, 464

  • Topics: Cancer Research, Virology, Immunology, Oncology, Pediatrics, Epidemiology

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