Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis

1. Front Matter

   Pages i-viii

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2. Barriers of the Human Organism and Their Achilles’ Heels

   • György Berencsi III, Maria Takács

   Pages 1-50

3. Recent Results on the Development of Fetal Immune System: Self, Epigenetic Regulation, Fetal Immune Responses

   • Eva Ay, Krisztina Buzas, Ferenc Banati, Janos Minarovits

   Pages 51-82

4. The Role of Endogenous Retroviruses in the Formation of Syncytiotrophoblast and Materno-Fetal Barrier

   • Eva Ay, Ferenc Banati, Katalin Turi-Balog, Janos Minarovits

   Pages 83-104

5. Maternal-Fetal Infections with Human Viruses

   • György Berencsi III, Márta Csire

   Pages 105-169

6. The Mechanism and Significance of Integration and Vertical Transmission of Human Herpesvirus 6 Genome

   • Jesse H. Arbuckle, Shara Pantry, Peter G. Medveczky

   Pages 171-194

7. Maternal-Fetal Transmission of HBV

   • Purnima Bhat

   Pages 195-222

8. Polarised Transfer of Proteins Through the Syncytiotrophobalst and Tissue Culture Cell Lines

   • György Berencsi III, Katalin Ördög

   Pages 223-247

9. Function of Maternal Idiotypic and Anti-idiotypic Antibodies as Transgenerational Messengers

   • Hilmar Lemke, Radu I. Tanasa, Ahmad Trad, Hans Lange

   Pages 249-279

10. Fetal and Neonatal Illnesses Caused or Influenced by Maternal Transplacental IgG and/or Therapeutic Antibodies Applied During Pregnancy

    • György Berencsi III, Katalin N. Szomor

    Pages 281-333

11. Maternal-Fetal Microchimerism and Fetal-Juvenile Malignancies

    • György Berencsi III, Erzsébet Barcsay

    Pages 335-388

12. Maternal Tumours Associated with and Influenced by Pregnancy

    • György Berencsi III

    Pages 389-441

13. Back Matter

    Pages 443-464

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The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

• Bi-directional Microchimerism
• Maternal-fetal Transcitosis
• Pregnancy and Tumours
• Transgenerational Messenger Antibodies
• Vertical Transmission of HHV-6

From the reviews:

“This volume written by virology experts reviews in addition to the maternal-fetal interaction of human viruses, with emphasis on those which influence the development and tumorigenesis in the fetus and neonate. Of interest to virologists, obstetricians, neonatologists, immunologists and oncologists. A timely text.” (Pediatric Endocrinology Reviews (PER), Vol. 10 (2), January, 2013)

• , Division of Virology, National Center for Epidemiology, Budapest, Hungary

  György Berencsi III

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