Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease

1. Front Matter

   Pages I-VI

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2. An Introduction to Adherens Junctions: From Molecular Mechanisms to Tissue Development and Disease

   • Tony J. C. Harris

   Pages 1-5

3. How AJs Evolved

   1. Front Matter

      Pages 7-7

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   2. Evolution of the Cadherin–Catenin Complex

      • Oda Hiroki

      Pages 9-35

4. How Cadherins and Catenins Interact to Assemble AJs

   1. Front Matter

      Pages 37-37

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   2. The Three-Dimensional Structure of the Cadherin–Catenin Complex

      • Noboru Ishiyama, Mitsuhiko Ikura

      Pages 39-62

   3. Biophysics of Cadherin Adhesion

      • Deborah Leckband, Sanjeevi Sivasankar

      Pages 63-88

   4. Adherens Junction Assembly

      • Sergey Troyanovsky

      Pages 89-108

5. How AJs Interface with Other Cellular Machinery

   1. Front Matter

      Pages 109-109

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   2. The Cytoskeleton and Classical Cadherin Adhesions

      • Siew Ping Han, Alpha S. Yap

      Pages 111-135

   3. Immunoglobulin Superfamily Receptors and Adherens Junctions

      • Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori, Yoshimi Takai

      Pages 137-170

   4. Signaling from the Adherens Junction

      • Abbye E. McEwen, David E. Escobar, Cara J. Gottardi

      Pages 171-196

   5. Adherens Junction Turnover: Regulating Adhesion Through Cadherin Endocytosis, Degradation, and Recycling

      • Andrew P. Kowalczyk, Benjamin A. Nanes

      Pages 197-222

6. How AJs Affect Cell Behaviour and Multicellular Development

   1. Front Matter

      Pages 223-223

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   2. Adherens Junctions During Cell Migration

      • Sandrine Etienne-Manneville

      Pages 225-249

   3. Adherens Junctions and Cadherins in Drosophila Development

      • Annalisa Letizia, Marta Llimargas

      Pages 251-277

   4. Adherens Junctions in C. elegans Embryonic Morphogenesis

      • Stephen T. Armenti, Jeremy Nance

      Pages 279-299

   5. Cadherin Function During Xenopus Gastrulation

      • Rudolf Winklbauer

      Pages 301-320

   6. Adherens Junctions in Mammalian Development, Homeostasis and Disease: Lessons from Mice

      • Barbara Boggetti, Carien M. Niessen

      Pages 321-355

7. How AJs Affect Tissue Homeostasis and Disease

   1. Front Matter

      Pages 357-357

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Cell–cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology.
• How did AJs evolve?
• How do cadherins and catenins interact to assemble AJs and mediate adhesion?
• How do AJs interface with other cellular machinery to couple adhesion with the whole cell?
• How do AJs affect cell behaviour and multicellular development?
• How can abnormal AJ activity lead to disease?

• adherens junctions
• animal tissues
• cell adhesion
• disease
• multicellular development
• Protein Structure
• Receptors

• , Cell and Systems Biology, University of Toronto, Toronto, Canada

  Tony Harris

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