Overview
- Editors:
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Sunil C. Kaul
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National Institute of Advanced Industria, Tsukuba, Japan
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Renu Wadhwa
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Science & Technology (AIST), National Insitute of Advanced Industrial, Tsukuba, Japan
- The first full-length textbook on mortalin, a member of heat shock protein family
- Includes chapters on its abundance and functional significance in a variety of cancers
- Comprehensive chapters on its existence and function in a wide range of fauna
- Its role in neurological and old age disorders such as Parkinson's (PD) disease
- The application of various mortalin reagents for bioimaging and bio-markers
- All the authors are experts on their subject with many years of research experience
- Includes supplementary material: sn.pub/extras
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Table of contents (21 chapters)
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Structure and Function of Mortalin
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- Renu Wadhwa, Sunil C. Kaul
Pages 3-20
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- Custer C. Deocaris, Sunil C. Kaul, Renu Wadhwa
Pages 21-30
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- Wen-I Luo, James A. Cowan
Pages 31-54
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- Walter A. Baseler, Tara L. Croston, John M. Hollander
Pages 55-80
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Mortalin in Evolution2 Deocaris
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- Marie Le Pécheur, Geneviève Morrow, Robert M. Tanguay
Pages 83-95
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- Charles W. Walker, Ben Low, S. Anne Böttger
Pages 97-113
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Mortalin in Health and Disease
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Front Matter
Pages 127-127
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- Moran Saar, Oren Moskovich, Zvi Fishelson
Pages 129-137
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- Jinghua Jin, Jing Zhang, Travis J. Cook, Jake G. Hoekstra
Pages 139-158
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- Lena F. Burbulla, Rejko Krüger
Pages 159-177
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- Robin E. White, Yi-Bing Ouyang, Rona G. Giffard
Pages 179-190
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- Joseph P. Gabriele, Sarah E. Groleau, Ritesh P. Daya, Zdenek B. Pristupa, Ram K. Mishra
Pages 191-207
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- Alberto J. L. Macario, Francesco Cappello, Everly Conway de Macario
Pages 209-221
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Mortalin and Cancer
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Front Matter
Pages 223-223
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- Ohad Iosefson, Abdussalam Azem
Pages 225-244
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- Masayuki Kanai, Kenji Fukasawa
Pages 245-255
About this book
The phrase “Life, stress and death” connects three terms, but is there a biological basis for that? Are there molecules that are essential to/or mediate these phenomena? This contributory volume “Mortalin Biology: Life, Stress and Death” is a remarkable compilation of the research outcomes on the stress protein mortalin, a member of heat shock 70 family of proteins. The book is unique as it describes mortalin playing essential role in life, stress response and death either from cancer, when it becomes hyperactive or from neuro-degeneration, when it becomes hypoactive. The book provides up-to-date knowledge on mortalin with respect to its discovery, structure, evolutionary conservation, function and signal transduction in different organisms in a simple, but most comprehensive way, that besides offering an enjoyable and in-depth reading, prompts the reader to ask further questions to explore this protein with new ideas, approaches and experiments. Twenty-one chapters by the world leaders on the specific areas of mortalin research throw light on its multi-functionality, potentials for biotechnology, diagnostics and therapeutic values. Avenues of mortalin biology, yet unexplored, hold immense promises for future, and reading this volume provides an easy, enthusiastic and energetic head-on start.
Editors and Affiliations
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National Institute of Advanced Industria, Tsukuba, Japan
Sunil C. Kaul
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Science & Technology (AIST), National Insitute of Advanced Industrial, Tsukuba, Japan
Renu Wadhwa