Phosphoinositides I: Enzymes of Synthesis and Degradation

1. Front Matter

   Pages 1-1

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2. The Phosphatidylinositol 4-Kinases: Don’t Call it a Comeback

   • Shane Minogue, Mark G. Waugh

   Pages 1-24

3. PIP Kinases from the Cell Membrane to the Nucleus

   • Mark Schramp, Andrew Hedman, Weimin Li, Xiaojun Tan, Richard Anderson

   Pages 25-59

4. The Phospholipase C Isozymes and Their Regulation

   • Aurelie Gresset, John Sondek, T. Kendall Harden

   Pages 61-94

5. Phosphoinositide 3-Kinases—A Historical Perspective

   • Alex Toker

   Pages 95-110

6. PI3Ks—Drug Targets in Inflammation and Cancer

   • Matthias Wymann

   Pages 111-181

7. Phosphoinositide 3-Kinases in Health and Disease

   • Alessandra Ghigo, Fulvio Morello, Alessia Perino, Emilio Hirsch

   Pages 183-213

8. Phosphoinositide Phosphatases: Just as Important as the Kinases

   • Jennifer M. Dyson, Clare G. Fedele, Elizabeth M. Davies, Jelena Becanovic, Christina A. Mitchell

   Pages 215-279

9. The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease

   • Elizabeth M. Davies, David A. Sheffield, Priyanka Tibarewal, Clare G. Fedele, Christina A. Mitchell, Nicholas R. Leslie

   Pages 281-336

10. Erratum

    • Tamas Balla, Matthias Wymann, John D. York

    Pages 337-337

11. Back Matter

    Pages 334-334

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Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

• PI 3-kinase
• PTEN
• kinase
• phosphatase
• phosphoinositide

• , NICHD, National Institutes of Health, Bethesda, USA

  Tamas Balla

• , Cancer- and Immunobiology, University of Basel, Basel, Switzerland

  Matthias Wymann

• , Pharmacology and Cancer Biology, Duke University Medical Center, Durham, USA

  John D. York

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