Overview
- Authors:
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Ton J. Cleophas
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, Department Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
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Aeilko H. Zwinderman
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, Dept. Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, Netherlands
- The authors have both medical and mathematical backgrounds
- Based on famous modules from the Socrates educational project
- Eudipharm of the EC Innovative because of its explanatory rather than mathematical approach
- Emphasizes non-classical but increasingly frequently used methods such as equivalence testing, interaction assessment and analysis of genetic data
- Not equivalent to any current textbook on statistics
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Table of contents (67 chapters)
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Front Matter
Pages i-xxxv
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 1-14
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 15-39
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 41-60
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 61-68
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 69-75
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 77-93
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 95-101
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 103-108
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 109-117
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 119-131
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 133-138
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 139-147
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 149-159
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 161-176
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 177-186
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 187-197
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 199-218
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 219-225
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- Ton J. Cleophas, Aeilko H. Zwinderman
Pages 227-231
About this book
Thanks to the omnipresent computer, current statistics can include data files of many thousands of values, and can perform any exploratory analysis in less than seconds. This development, however fascinating, generally does not lead to simple results. We should not forget that clinical studies are, mostly, for confirming prior hypotheses based on sound arguments, and the simplest tests provide the best power and are adequate for such studies. In the past few years the authors of this 5th edition, as teachers and research supervisors in academic and top-clinical facilities, have been able to closely observe the latest developments in the field of clinical data analysis, and they have been able to assess their performance. In this 5th edition the 47 chapters of the previous edition have been maintained and upgraded according to the current state of the art, and 20 novel chapters have been added after strict selection of the most valuable and promising novel methods. The novel methods are explained using practical examples and step-by-step analyses readily accessible for non-mathematicians. All of the novel chapters have been internationally published by the authors in peer-reviewed journal, including the American Journal of Therapeutics, the European Journal of Clinical Investigation, The International journal of Clinical Pharmacology and therapeutics, and other journals, and permission is granted by all of them to use this material in the current book. We should add that the authors are well-qualified in their fields of knowledge. Professor Zwinderman is president-elect of the International Society of Biostatistics, and Professor Cleophas is past-president of the American College of Angiology. From their expertise they should be able to make adequate selections of modern methods for clinical data analysis for the benefit of physicians, students, and investigators. The authors, although from a different discipline, one clinician and one statistician, have been working and publishing together for over 10 years, and their research of statistical methodology can be characterized as a continued effort to demonstrate that statistics is not mathematics but rather a discipline at the interface of biology and mathematics. They firmly believe that any reader can benefit from this clinical approach to statistical data analysis.
Reviews
From the reviews of the fifth edition:
“‘Statistics Applied to Clinical Studies, 5
th Edition’ clearly explains most anything that might be worth knowing about clinical research statistics. The content is accessible to non-staticians and also has the breadth and depth to interest professional biostaticians.” (Norman M. Goldfarb, Journal of Clinical Research Best Practices, Vol. 9 (2), February, 2013)
Authors and Affiliations
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, Department Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
Ton J. Cleophas
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, Dept. Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, Netherlands
Aeilko H. Zwinderman
