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Stem Cells and Human Diseases

  • Book
  • © 2012

Overview

Editors:
  1. Rakesh Srivastava

    1. , Pharmacology and Toxicology, University of Kansas Medical Center, Kansas City, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Sharmila Shankar

    1. , Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Mechanisms by which stem cell regulate regulate cellular function and normal organ development
  • Mechanisms by which cancer stem cells regulate cancer initiation and progression
  • Role of cancer stem cells in drug resistance
  • Signaling pathways regulating self-renewal capacity of normal stem cells and cancer stem cells
  • Development of novel drugs to target cancer stem cells
  • Role of microRNA and genes in stem cells and cancer stem cells
  • Genetic and proteomic profiling in stem cells

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-ix
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  2. Cancer Stem Cells: Biology, Perspectives and Therapeutic Implications

    • Brahma N. Singh, Sharmila Shankar, Rakesh K. Srivastava
    Pages 1-22

  3. The Perspectives of Stem Cell-Based Therapy in Neurological Diseases

    • Wojciech Maksymowicz, Joanna Wojtkiewicz, Hanna KozÅ‚owska, Aleksandra Habich, Wlodek Lopaczynski
    Pages 23-60

  4. Stem Cell-Based Therapy for Lysosomal Storage Diseases

    • Brittni A. Scruggs, Xiujuan Zhang, Jeffrey M. Gimble, Bruce A. Bunnell
    Pages 61-90

  5. Drosophila Germline Stem Cells

    • Yalan Xing, Willis X. Li
    Pages 91-99

  6. Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation

    • Peiman Hematti, Jaehyup Kim, Minoo Battiwalla
    Pages 101-115

  7. Cancer Stem Cells in Solid Tumors, Markers and Therapy

    • Ortiz-Sánchez Elizabeth, González-Montoya José Luis, Langley Elizabeth, García-Carrancá Alejandro
    Pages 117-148

  8. Cancer Stem Cells: Paradigm Shifting or Perishing Concept?

    • Senthil K. Pazhanisamy, Keith Syson Chan
    Pages 149-174

  9. Genomics of Prostate Cancer

    • Kern Rei Chng, Shin Chet Chuah, Edwin Cheung
    Pages 175-196

  10. Ischemia, Reactive Radicals, Redox Signaling and Hematopoietic Stem Cells

    • Suman Kanji, Vincent J. Pompili, Hiranmoy Das
    Pages 197-216

  11. Cancer Stem Cell Models and Role in Drug Discovery

    • Rohit Duggal, Boris Minev, Angelo Vescovi, Aladar Szalay
    Pages 217-228

  12. Origins of Metastasis-Initiating Cells

    • Sara M. Nolte, Sheila K. Singh
    Pages 229-246

  13. The Reduction of Callus Formation During Bone Regeneration by BMP-2 and Human Adipose Derived Stem Cells

    • Claudia Keibl, Martijn van Griensven
    Pages 247-266

  14. Stem Cells and Leukemia

    • Vincenzo Giambra, Christopher R. Jenkins
    Pages 267-306

  15. The Role of Adult Bone Marrow Derived Mesenchymal Stem Cells, Growth Factors and Scaffolds in the Repair of Cartilage and Bone

    • Antal Salamon, Erzsébet Toldy
    Pages 307-322

  16. Worth the Weight: Adipose Stem Cells in Human Disease

    • Saleh Heneidi, Gregorio Chazenbalk
    Pages 323-351

  17. Neural Crest and Hirschsprung’s Disease

    • Kim Hei-Man Chow, Paul Kwong-Hang Tam, Elly Sau-Wai Ngan
    Pages 353-386

  18. Common Denominators of Self-renewal and Malignancy in Neural Stem Cells and Glioma

    • Grzegorz Wicher, Karin Holmqvist, Karin Forsberg-Nilsson
    Pages 387-418

  19. Stem-Like Cells from Brain Tumours or Vice Versa?

    • Sara G. M. Piccirillo
    Pages 419-431

  20. Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics

    • Rajneesh Pathania, Vadivel Ganapathy, Muthusamy Thangaraju
    Pages 433-450
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Keywords

About this book

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

Editors and Affiliations

  • , Pharmacology and Toxicology, University of Kansas Medical Center, Kansas City, USA

    Rakesh Srivastava

  • , Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA

    Sharmila Shankar

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