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Signaling Pathways and Molecular Mediators in Metastasis

  • Book
  • © 2012

Overview

Editors:
  1. Alessandro Fatatis

    1. Drexel University College of Medicine, Philadelphia, USA

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  • Learning about metastatic dissemination of different solid tumours from a single source
  • Contributors present their latest work in addition to literature review
  • Innovative objective of identifying common mediators of metastasis in different tumours

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction

    • Robert B. Den, Adam P. Dicker
    Pages 1-10

  3. Local Invasion

    1. Front Matter

      Pages 11-11
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  4. LOCAL INVASION

    1. Reactivation of Epithelial-Mesenchymal Transition in Invasive and Metastatic Cancer

      • Michael D. Amatangelo, Mark E. Stearns
      Pages 13-69

    2. Biomechanical ECM Switches and Tumor Metastasis

      • Jacquelyn J. Ames, Calvin P. H. Vary, Peter C. Brooks
      Pages 71-89

    3. Moving Aggressively: S100A4 and Tumor Invasion

      • Reniqua P. House, Sarah C. Garrett, Anne R. Bresnick
      Pages 91-113

    4. Regulation of TGF-β Signaling and Metastatic Progression by Tumor Microenvironments

      • Michael K. Wendt, William P. Schiemann
      Pages 115-141

    5. Rho GTPases and Their Activators, Guanine Nucleotide Exchange Factors (GEFs): Their Roles in Glioma Cell Invasion

      • Bo Hu, Marc Symons, Bodour Salhia, Shannon P. Fortin, Nhan L. Tran, James Rutka et al.
      Pages 143-169

    6. Impact of Tumor Hypoxia, Src, and Met Signaling in the Dissemination of Tumor Cells

      • Yao Dai, Wenyin Shi, Nikolett Molnar, Dietmar Siemann
      Pages 171-194

  5. Homing and Colonization at Distant Sites

    1. Front Matter

      Pages 195-195
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  6. HOMING AND COLONIZATION AT DISTANT SITES

    1. Cellular and Molecular Biology of Cancer Cell Extravasation

      • J. Matthew Barnes, Michael D. Henry
      Pages 197-219

    2. Role of CXCL12 and CXCR4 in Tumor Biology and Metastasis

      • Ramesh K. Ganju, Yadwinder S. Deol, Mohd W. Nasser
      Pages 221-243

    3. Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases

      • Tuomas K. Mirtti, Pooja Talati, Marja T. Nevalainen
      Pages 245-260

    4. Survival and Growth of Prostate Cancer Cells in the Bone: Role of the Alpha-Receptor for Platelet-Derived Growth Factor in Supporting Early Metastatic Foci

      • Qingxin Liu, Yun Zhang, Danielle Jernigan, Alessandro Fatatis
      Pages 261-275

    5. Androgen Receptor Regulation of Prostate Cancer Progression and Metastasis

      • R. S. Schrecengost, M. A. Augello, Karen E. Knudsen
      Pages 277-309

    6. Integrin Signaling in Angiogenesis and Metastatic Cancer Progression in the Brain

      • Mihaela Lorger, Brunhilde Felding-Habermann
      Pages 311-329

    7. Tumor and Host Determinants of Pulmonary Metastasis in Bladder Cancer

      • Neveen Said, Dan Theodorescu
      Pages 331-345

    8. The Influence of Metastatic Breast Cancer on the Bone Microenvironment

      • Andrea M. Mastro, Donna M. Sosnoski, Venkatesh Krishnan, Karen M. Bussard
      Pages 347-368

  7. Back Matter

    Pages 369-375
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Keywords

About this book

This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.

Editors and Affiliations

  • Drexel University College of Medicine, Philadelphia, USA

    Alessandro Fatatis

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