Overview
- Editors:
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Charisse Litchman
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, Department of Neurology, Columbia University, Stamford, USA
- First manuscript on desmoid tumors
- World renowned authors
- Encompasses topics of relevance to clinicians, scientific researchers and advocacy groups
- Provides concrete guidance for treatment planning
- Addresses molecular aberrations driving the inception of DT
- Includes supplementary material: sn.pub/extras
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Table of contents (14 chapters)
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The Identification and Treatment of Desmoid Tumors
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- Anastasia Constantinidou, Michelle Scurr, Ian Judson, Charisse Litchman
Pages 5-16
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- Wai Chin Foo, Alexander J. Lazar
Pages 17-28
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- Robert A. Lefkowitz, Sinchun Hwang, Jonathan Landa
Pages 47-75
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- Paxton V. Dickson, Raphael Pollock
Pages 77-90
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- Andrea Marrari, Suzanne George
Pages 91-104
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- Hani O. Al-Halabi, Yen-Lin Chen, John T. Mullen, Sam S. Yoon, Francis J. Hornicek, Thomas F. DeLaney
Pages 105-125
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- David S. Pryluck, Joseph P. Erinjeri
Pages 127-144
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Special Populations with Desmoid Tumors
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Front Matter
Pages 145-145
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- Aaron R. Weiss, Anthony Montag, Stephen X. Skapek
Pages 159-178
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Considerations for Current and Future Advancement in the Search for a Cure
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Front Matter
Pages 179-179
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- Robert T. Sweeney, Matt van de Rijn
Pages 181-193
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Back Matter
Pages 209-209
About this book
Desmoid Tumors (DT), also called Aggressive Fibromatoses, are a rare fibroblastic proliferative disease, with an incidence of 2 to 4 new cases per million people per year. Despite the absence of a metastatic potential, DT cause significant morbidity and at times mortality due to its locally invasive behaviour. The anatomical locations can be abdominal, extra-abdominal (often in the extremities) and intra-abdominal. This book is the first manuscript dedicated entirely to Desmoid Tumors. Written by prominent clinicians, researchers and advocacy group experts, patients and professionals alike will find this to be a comprehensive review. Clinical presentation, imaging guidelines and treatment paradigms are highlighted. Both the sporadic and heredity forms (Familial Adenomatous Polyposis) will be discussed. A thorough discussion on the unique issues in children with DT is included. A portion of the book will address the role of the APC gene, the β-catenin protein and the role of mutations in the genesis of DT. Emerging cutting edge research techniques will be revealed. Also included is a thoughtful discussion on the controversial labelling of Desmoid Tumors as benign and the consequences of such a designation. The role of advocacy groups in supporting research and in promoting awareness of rare diseases such as DT will be outlined. This book will serve as basis to prepare clinicians, researchers and patients to embark on the quest for a cure for Desmoid Tumors.
Editors and Affiliations
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, Department of Neurology, Columbia University, Stamford, USA
Charisse Litchman