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Mouse as a Model Organism

From Animals to Cells

  • Book
  • © 2011

Overview

Editors:
  1. Cord Brakebusch

    1. , Institute of Biomedicine, BRIC, University of Copenhagen, Copenhagen, Denmark

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  2. Taina Pihlajaniemi

    1. Oulu Center for Cell-Matrix Research, Oulu, Finland

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    You can also search for this editor in PubMed   Google Scholar

  • High-level articles interesting for beginners and experienced scientists in mouse model research
  • Describes state-of-the-art, chances, and current problems in mouse model research In the post-genomic era, use of in vivo models is mandatory
  • This book gives an excellent introduction to the use of mice as a model organism

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Genomic Insulators in Transgenic Animals

    • Eduardo Moltó, Cristina Vicente-García, Almudena Fernández, Lluís Montoliu
    Pages 1-10

  3. The German Mouse Clinic – Running an Open Access Platform

    • Valérie Gailus-Durner, Beatrix Naton, Thure Adler, Luciana Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker et al.
    Pages 11-44

  4. Nature and Nurture: Impacts on Mouse Phenotypes and Translational Research

    • Cory Brayton
    Pages 45-76

  5. The Informatics of High-Throughput Mouse Phenotyping: EUMODIC and Beyond

    • John M. Hancock, Hilary Gates
    Pages 77-87

  6. Experimental Tumour Models in Mice

    • Ritva Heljasvaara, Taina Pihlajaniemi
    Pages 89-104

  7. Exploration of MMP Function in Mouse Models of Angiogenesis

    • Anne Masset, Mehdi El Hour, Sarah Berndt, Nor Eddine Sounni, Agnès Noel
    Pages 105-115

  8. Tumor-Stroma Interactions: Focus on Fibroblasts

    • Donald Gullberg, Rolf K. Reed
    Pages 117-130

  9. Experimental Procedures to Assay Invasion-Associated Activities of Primary Cultured Fibroblasts

    • An Hendrix, Koen Jacobs, Astrid De Boeck, Wendy Westbroek, Marc Bracke, Olivier De Wever
    Pages 131-143

  10. Systemic Instigation: A Mouse Model to Study Breast Cancer as a Systemic Disease

    • Sandra S. McAllister
    Pages 145-162

  11. Back Matter

    Pages 163-165
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Keywords

About this book

Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium “Mouse as a Model Organism – From Animals to Cells”, held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research.

Reviews

“The book gives a good introduction to the possible way of exploiting the mouse system to explore the molecular pathways underlying human diseases, especially cancer. The concept of ‘mouse clinics’ and the high throughput phenotyping of mouse mutants … described in the books will be watched with bated breath by all investigators of biomedical research, as these are the signposts of things to come in future.” (N. V. Giridharan, Indian Journal of Medical Research, Vol. 136, October, 2012)

Editors and Affiliations

  • , Institute of Biomedicine, BRIC, University of Copenhagen, Copenhagen, Denmark

    Cord Brakebusch

  • Oulu Center for Cell-Matrix Research, Oulu, Finland

    Taina Pihlajaniemi

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