Molecular Basis of Health and Disease

1. Front Matter

   Pages 1-1

   PDF

2. Introduction

   • Undurti N. Das

   Pages 1-10

3. Health and Disease as Two Sides of the Same Coin

   • Undurti N. Das

   Pages 11-13

4. Inflammation

   • Undurti N. Das

   Pages 15-100

5. Essential Fatty Acids—Biochemistry, Physiology and Clinical Significance

   • Undurti N. Das

   Pages 101-151

6. Cell Membrane Organization

   • Undurti N. Das

   Pages 153-173

7. Low-grade Systemic Inflammation is Present in Common Diseases/Disorders

   • Undurti N. Das

   Pages 175-179

8. Obesity

   • Undurti N. Das

   Pages 181-238

9. Hypertension

   • Undurti N. Das

   Pages 239-275

10. Insulin Resistance, Dyslipidemia, Type 2 Diabetes Mellitus and Metabolic Syndrome

    • Undurti N. Das

    Pages 277-332

11. Atherosclerosis

    • Undurti N. Das

    Pages 333-357

12. Osteoporosis

    • Undurti N. Das

    Pages 359-376

13. Alzheimer’s Disease, Schizophrenia and Depression

    • Undurti N. Das

    Pages 377-415

14. Rheumatological Conditions

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    Pages 417-464

15. Cancer

    • Undurti N. Das

    Pages 465-489

16. Aging

    • Undurti N. Das

    Pages 491-512

17. Adult Diseases and Low-Grade Systemic Inflammation Have Their Origins in the Perinatal Period

    • Undurti N. Das

    Pages 513-549

18. Clinical Implications

    • Undurti N. Das

    Pages 551-573

19. Back Matter

    Pages 566-566

    PDF

The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.

• Metabolic syndrome
• Obesity
• Polyunsaturated fatty acids
• Rheumatology
• Type 2 diabetes mellitus
• diabetes

• UND Life Science, Shaker Heights, USA

  Undurti N. Das

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