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Molecular Basis of Health and Disease

  • Book
  • © 2011

Overview

Authors:
  1. Undurti N. Das

    1. UND Life Science, Shaker Heights, USA

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  • Perinatal origins of adult diseases
  • Adult diseases as low-grade systemic inflammatory conditions
  • Inflammation as the basis of obesity, insulin resistance, metabolic syndrome and cancer
  • Imbalance in the pro- and anti-inflammatory molecules as the basis of adult diseases
  • Altered metabolism of essential fatty acids and eicosanoids in the pathobiology of adult diseases
  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages 1-1
    Download chapter PDF

  2. Introduction

    • Undurti N. Das
    Pages 1-10

  3. Health and Disease as Two Sides of the Same Coin

    • Undurti N. Das
    Pages 11-13

  4. Inflammation

    • Undurti N. Das
    Pages 15-100

  5. Essential Fatty Acids—Biochemistry, Physiology and Clinical Significance

    • Undurti N. Das
    Pages 101-151

  6. Cell Membrane Organization

    • Undurti N. Das
    Pages 153-173

  7. Low-grade Systemic Inflammation is Present in Common Diseases/Disorders

    • Undurti N. Das
    Pages 175-179

  8. Obesity

    • Undurti N. Das
    Pages 181-238

  9. Hypertension

    • Undurti N. Das
    Pages 239-275

  10. Insulin Resistance, Dyslipidemia, Type 2 Diabetes Mellitus and Metabolic Syndrome

    • Undurti N. Das
    Pages 277-332

  11. Atherosclerosis

    • Undurti N. Das
    Pages 333-357

  12. Osteoporosis

    • Undurti N. Das
    Pages 359-376

  13. Alzheimer’s Disease, Schizophrenia and Depression

    • Undurti N. Das
    Pages 377-415

  14. Rheumatological Conditions

    • Undurti N. Das
    Pages 417-464

  15. Cancer

    • Undurti N. Das
    Pages 465-489

  16. Aging

    • Undurti N. Das
    Pages 491-512

  17. Adult Diseases and Low-Grade Systemic Inflammation Have Their Origins in the Perinatal Period

    • Undurti N. Das
    Pages 513-549

  18. Clinical Implications

    • Undurti N. Das
    Pages 551-573

  19. Back Matter

    Pages 566-566
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Keywords

About this book

The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.

Authors and Affiliations

  • UND Life Science, Shaker Heights, USA

    Undurti N. Das

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