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Advances in Nuclear Architecture

  • Book
  • © 2011

Overview

Editors:
  1. Niall M. Adams

    1. Department of Mathematics, Imperial College, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Paul S. Freemont

    1. Div. Molecular Biosciences, Imperial College London, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • State of the art reviews from top researchers
  • Balanced emphasis on biological insight and quantitative analysis
  • First book on nuclear architecture that contains an emphasis on quantitative analysis
  • Includes supplementary material: sn.pub/extras

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-vii
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  2. Nuclear Subdomains and Cancer

    • Kendra L. Cann, Sui Huang, Graham Dellaire
    Pages 1-58

  3. Spatial Point Process Analysis of Promyelocytic Leukemia Nuclear Bodies

    • Philip P. Umande, David A. Stephens
    Pages 59-85

  4. Quantitative Approaches to Nuclear Architecture Analysis and Modelling

    • Daniel Hübschmann, Nikolaus Kepper, Christoph Cremer, Gregor Kreth
    Pages 87-129

  5. Statistical Shape Theory and Registration Methods for Analyzing the 3D Architecture of Chromatin in Interphase Cell Nuclei

    • Siwei Yang, Doris Illner, Kathrin Teller, Irina Solovei, Roel van Driel, Boris Joffe et al.
    Pages 131-147

  6. Nuclear Molecular Motors for Active, Directed Chromatin Movement in Interphase Nuclei

    • Joanna M. Bridger, Ishita S. Mehta
    Pages 149-172

  7. Methodology for Quantitative Analysis of 3-D Nuclear Architecture

    • Richard A. Russell, Niall M. Adams, David Stephens, Elizabeth Batty, Kirsten Jensen, Paul S. Freemont
    Pages 173-187

  8. Thinking Holistically About Gene Transcription

    • Dean A. Jackson
    Pages 189-205

  9. Back Matter

    Pages 207-210
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About this book

This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.

Editors and Affiliations

  • Department of Mathematics, Imperial College, London, United Kingdom

    Niall M. Adams

  • Div. Molecular Biosciences, Imperial College London, London, United Kingdom

    Paul S. Freemont

Bibliographic Information

  • Book Title: Advances in Nuclear Architecture

  • Editors: Niall M. Adams, Paul S. Freemont

  • DOI: https://doi.org/10.1007/978-90-481-9899-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2011

  • Hardcover ISBN: 978-90-481-9898-6Published: 20 October 2010

  • Softcover ISBN: 978-94-007-9809-0Published: 26 November 2014

  • eBook ISBN: 978-90-481-9899-3Published: 17 October 2010

  • Edition Number: 1

  • Number of Pages: VII, 210

  • Topics: Biomedicine general, Cell Biology, Gene Function, Cell Physiology

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