Detection of Biological Agents for the Prevention of Bioterrorism

1. Front Matter

   Pages i-xii

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2. Broadband Analysis of Bioagents by Mass Spectrometry

   • Catherine Fenselau, Colin Wynne, Nathan Edwards

   Pages 1-12

3. Hollow-Fiber Flow Field-Flow Fractionation for Mass Spectrometry: From Proteins to Whole Bacteria

   • Pierluigi Reschiglian, Andrea Zattoni, Diana Cristina Rambaldi, Aldo Roda, Myeong Hee Moon

   Pages 13-36

4. Mass Spectrometry and Tandem Mass Spectrometry for Protein Biomarker Discovery and Bacterial Speciation

   • Alvin Fox, Karen Fox

   Pages 37-45

5. Intact Cell/Spore Mass Spectrometry of Fusarium Macro Conidia for Fast Isolate and Species Differentiation

   • Hongjuan Dong, Martina Marchetti-Deschmann, Wolfgang Winkler, Hans Lohninger, Guenter Allmaier

   Pages 47-63

6. Bacteriophage Amplification-Coupled Detection and Identification of Bacterial Pathogens

   • Christopher R. Cox, Kent J. Voorhees

   Pages 65-82

7. Matrix Assisted Laser Desorption Ionization Mass Spectrometric Analysis of Bacillus anthracis: From Fingerprint Analysis of the Bacterium to Quantification of its Toxins in Clinical Samples

   • Adrian R. Woolfitt, Anne E. Boyer, Conrad P. Quinn, Alex R. Hoffmaster, Thomas R. Kozel, Barun K. De et al.

   Pages 83-97

8. Microorganism Identification Based On MALDI-TOF-MS Fingerprints

   • Thomas Elssner, Markus Kostrzewa, Thomas Maier, Gary Kruppa

   Pages 99-113

9. Mass Spectrometric Detection of Botulinum Neurotoxin by Measuring its Activity in Serum and Milk

   • Suzanne R. Kalb, James L. Pirkle, John R. Barr

   Pages 115-129

10. Functional Assays for Ricin Detection

    • Eric Ezan, Elodie Duriez, François Fenaille, François Becher

    Pages 131-147

11. Challenges of Detecting Bioterrorism Agents in Complex Matrices

    • Erica M. Hartmann, Rolf U. Halden

    Pages 149-162

12. DESI-MS/MS of Chemical Warfare Agents and Related Compounds

    • Paul A. D’Agostino

    Pages 163-179

13. Mass Spectrometry Applications for the Identification and Quantitation of Biomarkers Resulting from Human Exposure to Chemical Warfare Agents

    • J. Richard Smith, Benedict R. Capacio

    Pages 181-199

14. Applications of Mass Spectrometry in Investigations of Alleged Use of Chemical Warfare Agents

    • Robert W. Read

    Pages 201-219

15. Mass Spectrometry for the Analysis of Low Explosives

    • Bruce McCord, Megan Bottegal, John Mathis

    Pages 221-229

16. Identification of the Bacterial Cellular Lipid Fraction by Using Fast GC × GC-MS and Innovative MS Libraries

    • Luigi Mondello, Peter Quinto Tranchida, Giorgia Purcaro, Chiara Fanali, Paola Dugo, Erminia La Camera et al.

    Pages 231-244

17. Endotoxins in Environmental and Clinical Samples Assessed by GC-Tandem MS

    • Bogumila Szponar

    Pages 245-265

18. Imaging Mass Spectrometry

    • Michelle L. Reyzer, Richard M. Caprioli

    Pages 267-283

19. 2 and 3D TOF-SIMS Imaging for Biological Analysis

    • John S. Fletcher

    Pages 285-299

20. Application of Mass Spectrometry for the Analysis of Vitellogenin, a Unique Biomarker for Xenobiotic Compounds

    • Alejandro M. Cohen, Joseph H. Banoub

    Pages 301-318

The threat of biological and chemical terrorism has driven the demand for timely techniques that can quickly detect the agent or agents used in an attack. The detection and/or prevention of these potential security threats provide significant scientific and technical challenges due to the combination of possible agents and modes of delivery available. This book will present a thorough look at the importance and technological challenges of mass spectrometry (MS) for the detection & identification of biological and chemical threats. This new contribution’s general aims are to draw the attention of recognized practitioners, experts and graduate students trying to grasp the latest MS developments in the cutting-edge fields of MS-biodefense technologies for the rapid/early/specific sensitive threat detection of pathogens, viruses, explosives, mycotoxins, chemical agents, and biological markers of xenobiotic chemicals.

• 2D Tissue Imaging
• Biology
• Chemistry
• Detection of Chemical Agents
• Detection of Explosives
• Detection of Extracted Bacterial Proteins
• Detection of Mycotoxins
• Detection of Specific Protein Biomarker
• MS Strategies
• NATO
• Peace
• Science
• Security
• Sub-Series A

• , Science Branch, Fisheries and Oceans Canada, St. John's, Canada

  Joseph Banoub

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