Cell Fusions

1. Front Matter

   Pages i-xii

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2. Regulation and Control of Cell–Cell Fusions

   • Lars-Inge Larsson

   Pages 1-9

3. Retroviruses and Cell Fusions: Overview

   • Anders L. Kjeldbjerg, Shervin Bahrami, Finn Skou Pedersen

   Pages 11-39

4. Retroviral Membrane Fusions: Regulation by Proteolytic Processing and Cellular Factors

   • Yoshinao Kubo

   Pages 41-61

5. A Comparative Portrait of Retroviral Fusogens and Syncytins

   • Philippe Pérot, Cécile Montgiraud, Dimitri Lavillette, François Mallet

   Pages 63-115

6. Syncytins: Molecular Aspects

   • Hungwen Chen, Mei-Leng Cheong

   Pages 117-137

7. Role of the Actin Cytoskeleton Within FuRMAS During Drosophila Myoblast Fusion and First Functionally Conserved Factors in Vertebrates

   • Susanne-Filiz Önel, Christine Dottermusch, Angela Sickmann, Detlev Buttgereit, Renate Renkawitz-Pohl

   Pages 139-170

8. Role of CD9 in Sperm-Egg Fusion and Its General Role in Fusion Phenomena

   • Natsuko Kawano, Yuichiro Harada, Keiichi Yoshida, Mami Miyado, Kenji Miyado

   Pages 171-184

9. Gamete Binding and Fusion

   • Young-Joo Yi, Shawn W. Zimmerman, Peter Sutovsky

   Pages 185-201

10. Mechanisms Regulating Human Trophoblast Fusion

    • Berthold Huppertz, Martin Gauster

    Pages 203-217

11. Macrophage Fusion: The Making of a New Cell

    • Agnès Vignery

    Pages 219-231

12. Molecules Regulating Macrophage Fusions

    • Takeshi Miyamoto, Toshio Suda

    Pages 233-248

13. Current Progress Towards Understanding Mechanisms of Myoblast Fusion in Mammals

    • Grace K. Pavlath

    Pages 249-265

14. The Endogenous Envelope Protein Syncytin Is Involved in Myoblast Fusion

    • Bolette Bjerregaard, Jan Fredrik Talts, Lars-Inge Larsson

    Pages 267-275

15. Cell Fusion and Stem Cells

    • Alain Silk, Anne E. Powell, Paige S. Davies, Melissa H. Wong

    Pages 277-314

16. Cell Fusion and Dendritic Cell-Based Vaccines

    • Jianlin Gong, Shigeo Koido

    Pages 315-350

17. Cancer Cell Fusion with Myeloid Cells: Implications for Energy Metabolism in Malignant Hybrids

    • Rossitza Lazova, Ashok K. Chakraborty, John M. Pawelek

    Pages 351-394

18. Cell–Cell Fusions and Human Endogenous Retroviruses in Cancer

    • Reiner Strick, Matthias W. Beckmann, Pamela L. Strissel

    Pages 395-426

19. Back Matter

    Pages 427-436

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Cell fusions are important to fertilization, placentation, development of skeletal muscle and bone, calcium homeostasis and the immune defence system. Additionally, cell fusions participate in tissue repair and may be important to cancer development, progression and therapy. A large number of factors regulate cell fusions, including receptors and ligands, membrane domain organizing proteins, proteases, signaling molecules and fusogenic proteins that bring membranes close together. In the present volume, we interrogate what mechanisms that may be important to cell fusions in mammals and what mechanisms that may be shared with lower organisms and viruses. Additionally, the importance of cell fusions to the pathogenesis as well as treatment of diseases is addressed.

• Faculty of Life Sciences, Division of Cell Biology, University of Copenhagen, Frederiksberg C, Denmark

  Lars-Inge Larsson

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