Sarcopenia – Age-Related Muscle Wasting and Weakness

1. Front Matter

   Pages i-xiii

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2. Overview of Sarcopenia

   • Gordon S. Lynch

   Pages 1-7

3. Muscle Wasting in Cancer and Ageing: Cachexia Versus Sarcopenia

   • Josep M. Argilés, Sílvia Busquets, Marcel Orpi, Roberto Serpe, Francisco J. López-Soriano

   Pages 9-35

4. Age-Related Remodeling of Neuromuscular Junctions

   • Carlos B. Mantilla, Gary C. Sieck

   Pages 37-54

5. Aging-Related Changes Motor Unit Structure and Function

   • Alexander Cristea, David E. Vaillancourt, Lars Larsson

   Pages 55-74

6. Age-Related Decline in Actomyosin Structure and Function

   • LaDora V. Thompson

   Pages 75-111

7. Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle

   • Osvaldo Delbono

   Pages 113-134

8. Alterations in Mitochondria and Their Impact in Aging Skeletal Muscle

   • Russell T. Hepple

   Pages 135-158

9. Skeletal Muscle Collagen: Age, Injury and Disease

   • Luc E. Gosselin

   Pages 159-172

10. Nuclear Apoptosis and Sarcopenia

    • Stephen E. Alway, Parco M. Siu

    Pages 173-206

11. Age-Related Changes in the Molecular Regulation of Skeletal Muscle Mass

    • Aaron P. Russell, Bertrand Lèger

    Pages 207-221

12. Genetic Variation and Skeletal Muscle Traits: Implications for Sarcopenia

    • Stephen M. Roth

    Pages 223-257

13. Proteomic and Biochemical Profiling of Aged Skeletal Muscle

    • Kathleen O’Connell, Philip Doran, Joan Gannon, Pamela Donoghue, Kay Ohlendieck

    Pages 259-287

14. Exercise and Nutritional Interventions to Combat Age-Related Muscle Loss

    • René Koopman, Lex B. Verdijk, Luc J. C. van Loon

    Pages 289-315

15. Reactive Oxygen Species Generation and Skeletal Muscle Wasting – Implications for Sarcopenia

    • Anne McArdle, Malcolm J. Jackson

    Pages 317-331

16. Exercise as a Countermeasure for Sarcopenia

    • Donato A. Rivas, Roger A. Fielding

    Pages 333-371

17. Role of Contraction-Induced Injury in Age-Related Muscle Wasting and Weakness

    • John A. Faulkner, Christopher L. Mendias, Carol S. Davis, Susan V. Brooks

    Pages 373-391

18. Role of IGF-1 in Age-Related Loss of Skeletal Muscle Mass and Function

    • Chris D. McMahon, Thea Shavlakadze, Miranda D. Grounds

    Pages 393-418

19. Role of Myostatin in Skeletal Muscle Growth and Development: Implications for Sarcopenia

    • Craig McFarlane, Mridula Sharma, Ravi Kambadur

    Pages 419-447

20. Role of β-Adrenergic Signalling in Skeletal Muscle Wasting: Implications for Sarcopenia

    • James G. Ryall, Gordon S. Lynch

    Pages 449-471

Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. Not surprisingly, sarcopenia is a significant public health problem throughout the developed world. There is an urgent need to better understand the neuromuscular mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse sarcopenia. Significant research and development in academic and research institutions and in pharmaceutical companies is being directed to sarcopenia and to related health issues in order to develop and evaluate novel therapeutics. This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders. The book provides a vital resource for researchers and practitioners alike, with information relevant to gerontologists, geriatricians, sports medicine physicians, physiologists, neuroscientists, cell biologists, endocrinologists, physical therapists, allied health and musculoskeletal practitioners, strength and conditioning specialists, athletic trainers, and students of the medical and biomedical sciences.

• Aging
• Neuromuscular biology
• Skeletal muscle
• Sports medicine
• Therapy

• , Department of Physiology, The University of Melbourne, Melbourne, Australia

  Gordon S. Lynch

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