The Challenge of Highly Pathogenic Microorganisms

1. Front Matter

   Pages i-xviii

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2. The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics

   • Arthur M. Friedlander

   Pages 1-9

3. Proteomic Studies of Bacillus anthracis Reveal In Vitro CO₂-Modulation and Expression During Infection of Extracellular Proteases

   • Theodor Chitlaru, Orit Gat, Galia Zaide, Haim Grosfeld, Izhak Inbar, Sharon Ehrlich et al.

   Pages 11-22

4. Dynamics of Bacillus anthracis Infection and Control Mechanisms

   • Pierre L. Goossens, Ian J. Glomski, Lhousseine Touqui, Michèle Mock

   Pages 23-29

5. Survival and Trafficking of Yersinia pestis in Non-acidified Phagosomes in Murine Macrophages

   • James B. Bliska

   Pages 31-44

6. The Inverse Relationship Between Cytotoxicity of Y. pestis and Its Virulence

   • Emanuelle Mamroud, Avital Tidhar, Yinon Levy, Erez Bar-Haim, Gideon Halperin, Yehuda Flashner et al.

   Pages 45-55

7. The NlpD Lipoprotein of Yersinia pestis is Essential for Cell Separation and Virulence

   • Avital Tidhar, Yehuda Flashner, Sara Cohen, Yinon Levy, Ayelet Zauberman, David Gur et al.

   Pages 57-65

8. Dissection of the Functions of the IglC Protein of Francisella tularensis

   • Jeanette E. Bröms, Moa Lavander, Anders Sjöstedt

   Pages 67-75

9. Yersinia pestis Lipopolysaccharide in Host-Pathogen Interactions

   • Andrey P. Anisimov, Svetlana V. Dentovskaya, Anna N. Kondakova, Buko Lindner, Rima Z. Shaikhutdinova, Nina A. Kocharova et al.

   Pages 77-87

10. The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization

    • Baruch Velan, Erez Bar-Haim, Gal Markel, Hila Cohen, Ayelet Zauberman, Sara Cohen et al.

    Pages 89-98

11. Comparative Approaches to Identify Host Factors Specifically Targeted by Yersinia pestis During the Infectious Process

    • Françoise Guinet, Patrick Avé, Louis Jones, Michel Huerre, Elisabeth Carniel

    Pages 99-106

12. Poxvirus Entry into Host Cells

    • Bernard Moss, Zain Bengali, Himani Bisht, Jason P. Laliberte, P.S. Satheskumar

    Pages 107-113

13. Role of A33R Amino-Acid 118L in the Interactions of Vaccinia Virus with the Host

    • Nir Paran, Shlomo Lustig, Anat Zvi, Tomer Israely, Sharon Melamed, Noam Erez et al.

    Pages 115-123

14. Inhibitors of Innate Immunity from Vaccinia Virus

    • Geoffrey L. Smith

    Pages 125-134

15. Brucella Species Synchronize Their Life Cycle to the Gestation Cycle of Their Ruminant Hosts

    • Svetlana Bardenstein, Menachem Banai

    Pages 135-146

16. MMP-9 as a Marker for Vaccinia Virus Related Encephalitis

    • Tomer Israely, Sharon Melamed, Noam Erez, Boaz Politi, Udy Olshevsky, Reuven Levin et al.

    Pages 147-155

17. Epidemic Cowpox Virus Infections in Germany

    • Andreas Kurth, Andreas Nitsche

    Pages 157-164

18. The Two Partner Secretion Transporters of Yersinia pestis: Cloning, Immunogenicity and In Vivo Expression Following Airway Infection

    • Yinon Levy, Anat Zvi, Haim Grosfeld, Avital Tidhar, David Gur, Yehuda Flashner et al.

    Pages 165-172

19. Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX)

    • Adi Beth-Din, Ofir Israeli, Ohad Shifman, Dana Stein, Einat Ben-Arie, Nir Paran et al.

    Pages 173-182

20. Subtyping Biothreat Bacterial Pathogens

    • Paul Keim, Talima Pearson

    Pages 183-190

The OHOLO conferences are sponsored by the Israel Institute for Biological Research and take their name from the site of the ?rst meeting on the shores of Lake Kinnereth. The purpose of these meetings is, as it was at their inception over 50 years ago, “to foster interdisciplinary communication between scientists in Israel, and to provide added stimulus by the participation of invited scientists from abroad”. The core of the organizers of the OHOLO conferences are scientists from the Israel Institute for Biological Research. From time to time a particular OHOLO conference cooperates with an international scienti?c organization. The present 46th OHOLO Conference marks the resumption of the OHOLO tradition after 8 years of interruption caused by events beyond our control. It is my belief that our uncomp- mising commitment to excellence in research and development in the various areas of science in Israel is essential to our survival in this troubled region. The OHOLO conference tradition is a re?ection of this conviction. The present 46th OHOLO Conference entitled: The Challenge of Highly Pathogenic Microorganisms – Mechanisms of Virulence and Novel Medical Countermeasures intends to address the unique virulence features and ho- pathogen interactions of microorganisms constituting emerging biothreat with emphasis on Y. pestis, B. anthracis, F. tularensis and Orthopox viruses. Accordingly we selected classical microbiological as well as genomic, proteomic & transcr- tomic approaches towards developments of novel prophylactic and post-exposure treatment, as well as updated strategies of diagnostics and bioforensics.

• Toxin
• infections
• microorganism
• protein
• virus
• vaccines

• Israel Institute for Biological Research, Ness-Ziona, Israel

  Avigdor Shafferman, Arie Ordentlich, Baruch Velan

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