Genetic Disorders of the Indian Subcontinent

1. Front Matter

   Pages i-xviii

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2. Human Genetics and the Indian Subcontinent

   1. The Indian Subcontinent and Human Genetics: An Introduction

      • Dhavendra Kumar

      Pages 1-27

   2. Ethnic and Cultural Diversity

      • Paramjit S. Gill, Jagbir Jhutti-Johal, Anil Gumber

      Pages 29-55

   3. Genomic and Gene Diversity among the People of the Indian Subcontinent

      • Sarabjit S. Mastana, Surinder S. Papiha

      Pages 57-80

   4. Epidemiology of Genetic Diseases

      • Ishwar C. Verma, Dhavendra Kumar

      Pages 81-87

   5. Immunogenetic Basis of Variation and Disease Susceptibility

      • Narinder K. Mehra, Gurvinder Kaur, Ritika Jaini

      Pages 89-123

   6. Consanguinity: Cultural, Religious and Social Aspects

      • Rafat Hussain

      Pages 125-135

3. Selected Genetic Disorders

   1. Congenital Developmental Anomalies

      • Dhavendra Kumar

      Pages 137-154

   2. Malformation Syndromes in India

      • Shubha R. Phadke

      Pages 155-166

   3. Down Syndrome In India

      • Rajiva Raman

      Pages 167-180

   4. Inherited Metabolic Diseases among South Asians in the United Kingdom

      • Maureen Cleary, Anupam Chakrapani

      Pages 181-205

   5. Management of Inherited Metabolic Diseases in India

      • Bal N. Apte

      Pages 207-222

   6. Indian Childhood Cirrhosis and Other Metabolic Liver Diseases

      • Ashish Bavdekar, Stuart Tanner

      Pages 223-243

   7. Thalassaemias and Other Haemoglobinopathies

      • John Old

      Pages 245-264

   8. Disorders of Haemostasis and Thrombosis

      • Liakat Parapia

      Pages 265-274

   9. Glucose-6-Phosphate Dehydrogenase Deficiency and Other Inherited Red Cell Defects

      • Roderick Hinchliffe, Ajay Vora

      Pages 275-290

   10. Genetic Neurological and Psychiatric Diseases

       • Dhavendra Kumar, Michael A. Patton, Ajith Kumar

       Pages 291-312

   11. Inherited Skeletal Dysplasias and Collagen Diseases

       • Sanjeev Madan, James A. Fernandes, Dhavendra Kumar

       Pages 313-345

   12. Deafness and Related Syndromes

       • M. J. Parker, I. D. Young, T. P. Hutchin

       Pages 347-367

   13. Genetics Diseases of the Eye in India

       • Govindasamy Kumaramanickavel

       Pages 369-398

The Indian subcontinent is a vast land mass inhabited by over one billion people. Its rich and varied history is reflected by its numerous racial and ethnic groups and its distinct religious, cultural and social characteristics. Like many developing countries in Asia, it is passing through both demographic and epidemiological transitions whereby, at least in some parts, the diseases of severe poverty are being replaced by those of Westemisation; obesity, diabetes, and heart disease, for example. Indeed, as we move into the new millennium India has become a land of opposites; on the one hand there is still extensive poverty yet, on the other hand, some of the most remarkable developments in commerce and technology in Asia are taking place, notably in the fields of information technology and biotechnology. India has always fascinated human geneticists and a considerable amount of work has been done towards tracing the origins of its different ethnic groups. In the current excitement generated by the human genome project and the molecular and genetic approach to the study of human disease, there is little doubt that this field will develop and flourish in India in the future. Although so far there are limited data about genetic diseases in India, enough is known already to suggest that this will be an extremely fruitful area of research.

• Chromosom
• developing countries
• development
• genetics
• infection
• koffie
• nutrition
• pain
• thrombosis

From the reviews of the first edition:

"To the best of our knowledge, this is the only book written and compiled to focus on human genetics and genetic disorders in relation to people of the Indian subcontinent. It is hoped that the reader will have a good overview and background information on the key subjects ranging from social and cultural aspects to the application of the science of human genetics in the practice of modern clinical medicine."
(Dhavendra Kumar)
"This is excellent and long overdue"
(Professor Bhuki Parekh, London School of Economics, UK)

"Genetic disorders of the Indian subcontinent is a comprehensive and timely book that addresses the burden of genetic disorders in the people of the Indian subcontinent. … There is an admirable attempt to explain the complex interaction of age-old beliefs, social practices, cultural influences … . This book is an invaluable resource to all clinicians dealing with genetic disorders among this population not only in the subcontinent but even in other countries such as UK where there is a sizeable population from this region." (Charulata Deshpande, Human Genetics, Vol. 120, 2006)

• Department of Clinical Genetics, The Churchill Hospital, Oxford Radcliffe Hospitals NHS Trust, Headington, UK

  Dhavendra Kumar

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