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Cell Culture Methods for In Vitro Toxicology

  • Book
  • © 2001

Overview

Editors:
  1. Glyn N. Stacey

    1. National Institute of Biological Standards and Control, Potters Bar, UK

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  2. Alan Doyle

    1. The Wellcome Trust, London, UK

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  3. Margherita Ferro

    1. University of Genova, Italy

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-ix
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  2. Standardisation for In Vitro Toxicity Tests

    • Margherita Ferro, Alan Doyle
    Pages 1-8

  3. Application of Cell Cultures to Toxicology

    • Ian Freshney
    Pages 9-26

  4. Immortalisation of Primary Cells

    • Glyn Stacey, Caroline MacDonald
    Pages 27-42

  5. Safety Considerations for In Vitro Toxicology Testing

    • Bruce Jones, Glyn Stacey
    Pages 43-66

  6. The Drug-Metabolizing Enzymatic System and the Experimental Tools used for In Vitro Toxicology for Metabolic Studies

    • Emanuela Testai
    Pages 67-81

  7. Cell Culture Models for Hepatotoxicology

    • Thierry Battle, Glyn Stacey
    Pages 83-95

  8. Intestinal Cell Culture Models

    • Yula Sambruy, S. Ferruzza, G. Ranaldi, I. De Angelis
    Pages 97-113

  9. Cell Culture Models for Neurotoxicology

    • Glyn Stacey, Barbara Viviani
    Pages 115-130

  10. Recombinant Cell Lines for Stress Reporter Assays

    • Michel Fischbach, Peter Bromley
    Pages 131-147

  11. Back Matter

    Pages 149-153
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Keywords

About this book

Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation these are key issues for in vitro systems addressing the `3Rs' principle. Up-to-date overviews deal with the use of cells from liver, brain and intestine. In addition, biochemical analysis of cell responses, biotransformation pathways in cells and recombinant approaches to the early detection of cell stress are also covered in detail.
Prominent features of in vitro technologies also include regulation, biosafety and standardisation. Dedicated chapters deal with these issues in a practical way in order to lead the reader to the right source of information. This book provides an up-to-date, informative and practical review of cell culture methods for in vitro toxicology. It will be of equal benefit to students and experienced toxicologists with little experience of in vitro cell culture.

Editors and Affiliations

  • National Institute of Biological Standards and Control, Potters Bar, UK

    Glyn N. Stacey

  • The Wellcome Trust, London, UK

    Alan Doyle

  • University of Genova, Italy

    Margherita Ferro

Bibliographic Information

  • Book Title: Cell Culture Methods for In Vitro Toxicology

  • Editors: Glyn N. Stacey, Alan Doyle, Margherita Ferro

  • DOI: https://doi.org/10.1007/978-94-017-0996-5

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 2001

  • Hardcover ISBN: 978-1-4020-0427-8Published: 31 December 2001

  • Softcover ISBN: 978-90-481-5936-9Published: 04 December 2010

  • eBook ISBN: 978-94-017-0996-5Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: IX, 153

  • Topics: Pharmacology/Toxicology, Animal Anatomy / Morphology / Histology, Pharmacy

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