Overview
- Editors:
-
-
Norman S. Wolf
-
Seattle, U.S.A.
- The first book devoted exclusively and comprehensively to the Comparative Biology of Aging
- Compares as many species as possible for the biological and molecular changes that occur with aging
- Discussing aging changes in various cells tissues and organs as well as the regimens and treatments that delay or accelerate their aging
- Broadly focussed, both from a multi-species approach and a multi-tissue approach
- The contributing chapter authors are experts in their fields
- Both cell and organelle aging as well as full systemic changes are discussed
Access this book
Other ways to access
Table of contents (15 chapters)
-
-
- Norman S. Wolf, Steven Austad
Pages 1-26
-
-
- Adam Spong, Andrzej Bartke
Pages 43-68
-
- Rozalyn M. Anderson, Ricki J. Colman, Richard Weindruch
Pages 69-96
-
-
- Daniel L. Smith Jr., Jeffrey S. Smith
Pages 123-146
-
- Matt Kaeberlein, Lara S. Shamieh
Pages 147-161
-
- Yun Shi, Rochelle Buffenstein, Holly Van Remmen
Pages 163-190
-
- Jan Vijg, Ana Maria Garcia, Brent Calder, Martijn Dollé
Pages 191-200
-
- Samantha J. Orenstein, Ana Maria Cuervo
Pages 201-226
-
- N.M.V. Gomes, J.W. Shay, W. E. Wright
Pages 227-258
-
- Dao-Fu Dai, Robert J. Wessells, Rolf Bodmer, Peter S. Rabinovitch
Pages 259-286
-
- David J. Marcinek, Jonathan Wanagat, Jason J. Villarin
Pages 287-317
-
- Catherine A. Wolkow, Sige Zou, Mark P. Mattson
Pages 319-352
-
- Janko Nikolich-Žugich, Luka Čičin-Šain
Pages 353-376
-
Back Matter
Pages 377-391
About this book
determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].
Editors and Affiliations
-
Seattle, U.S.A.
Norman S. Wolf
