Editors:
- The first book with a unique focus on the effects of extracellular nucleotides and adenosine in endothelial cells.
- Describes regulatory role of extracellular nucleotides and adenosine in angiogenesis, vascular permeability, cell-to-cell communication, inflammation and wound healing.
- Includes cutting edge experimental approaches in pharmacology, enzymology, signal transduction, transgenic and knockout animal models.
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Table of contents (12 chapters)
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Front Matter
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Back Matter
About this book
Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis.
This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication.
This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes.
In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented.
In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds.
This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.
Editors and Affiliations
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Dept. Pediatrics, Pediatric Clinical Services, University of Colorado, Denver, Aurora, USA
Evgenia Gerasimovskaya
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Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Elzbieta Kaczmarek
Bibliographic Information
Book Title: Extracellular ATP and adenosine as regulators of endothelial cell function
Book Subtitle: Implications for health and disease
Editors: Evgenia Gerasimovskaya, Elzbieta Kaczmarek
DOI: https://doi.org/10.1007/978-90-481-3435-9
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2010
Hardcover ISBN: 978-90-481-3434-2Published: 11 May 2010
Softcover ISBN: 978-94-007-9680-5Published: 07 November 2014
eBook ISBN: 978-90-481-3435-9Published: 26 April 2010
Edition Number: 1
Number of Pages: XI, 236
Topics: Molecular Medicine, Medical Biochemistry, Cytokines and Growth Factors, Cell Physiology, Pathology, Biomedicine general