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Table of contents (15 chapters)
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Front Matter
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Back Matter
About this book
Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease provides the most current review of the literature relating to the role and influence of heat shock (stress) proteins on the establishment, progression and resolution of infectious disease. Written by leaders in the field of heat shock proteins (HSP) and their biological and immunological properties, the contributors provide a fascinating insight into the complex relationship between, and the involvement of prokaryotic and eukaryotic HSP in disease states. It has been known for some considerable time that heat shock proteins from prokaryotic organisms are immunodominant molecules that are intimately involved in the induction of potential protective inflammatory responses, and this aspect of HSP biology is updated herein. In addition to regulating heat shock protein gene expression, the transcription factor HSF1 also appears to play an important role in regulating immune responses to infection. Heat shock proteins are now known to influence infectious disease processes in a number of diverse ways: they are involved in the propagation of prions, the replication and morphogenesis of viruses, and the resistance of parasites to chemotherapy. These proteins also appear to be important mediators of bacteria-host interactions and inflammation, the latter via interactions with cell surface molecules and structures such as Toll-like receptors and lipid rafts. Heat shock proteins can be expressed on the surface of infected cells, and this is likely to provide a target for the innate immune response. Elevated levels of circulating HSP are present in infectious diseases and these proteins might therefore regulate inflammatory responses to pathogenic challenge on a systemic basis. Heat shock proteins are also implicated in the impact of genital tract infections on the reproductive outcome, as well as in the local and systemic consequences of periodontal disease. Fever-range temperatures can induce the expression of heat shock proteins, and the final chapter in the book examines the influence of fever-range hyperthermia on a variety of cells and the organization of plasma membranes. This book is an essential read for graduates and postgraduates in Biology, pro- and eukaryotic Biochemistry, Immunology, Microbiology, Inflammatory and Infectious Disease, and Pathology.
Editors and Affiliations
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School of Medicine & Biomedical Science, University of Sheffield, Sheffield, United Kingdom
A. Graham Pockley
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Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, U.S.A.
Stuart K. Calderwood
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Dipto. Biologia, Università di Roma, Tor Vergata, Roma, Italy
M. Gabriella Santoro
Bibliographic Information
Book Title: Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease
Editors: A. Graham Pockley, Stuart K. Calderwood, M. Gabriella Santoro
Series Title: Heat Shock Proteins
DOI: https://doi.org/10.1007/978-90-481-2976-8
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2010
Hardcover ISBN: 978-90-481-2975-1Published: 27 November 2009
Softcover ISBN: 978-94-007-3087-8Published: 14 March 2012
eBook ISBN: 978-90-481-2976-8Published: 10 November 2009
Series ISSN: 1877-1246
Series E-ISSN: 1877-1254
Edition Number: 1
Number of Pages: XII, 312
Topics: Biomedicine general