Overview
- Editors:
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Deborah L. Hay
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School of Biological Sciences, University of Auckland, Auckland , New Zealand
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Ian M. Dickerson
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University of Auckland, Auckland, New Zealand
- Comprehensive compilation of reviews on CGRP, amylin, calcitonin, adrenomedullin and AM2/intermedin
- Useful reference work for researchers in the fields of CGRP, amylin, calcitonin, adrenomedullin and AM2/intermedin
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Table of contents (14 chapters)
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Front Matter
Pages i-viii
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- Yoshio Takei, Maho Ogoshi, Marty K. S. Wong, Shigenori Nobata
Pages 1-21
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- James Barwell, John Simms, Alex Conner, Debbie Hay, Mark Wheatley, David Poyner
Pages 23-40
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- Rasmus Just, John Simms, Sebastian G. B. Furness, Arthur Christopoulos, Patrick M. Sexton
Pages 41-57
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- Walter Born, Jan A. Fischer
Pages 75-86
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- Mahita Kadmiel, Kathleen M. Caron
Pages 87-95
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- Ki-Youb Park, Andrew F. Russo
Pages 97-114
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- Gabor Pozsgai, Lihuan Liang, Susan D. Brain
Pages 115-130
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- Chia Lin Chang, Sheau Yu Teddy Hsu
Pages 131-149
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- Weiya Ma, Jean-Guy Chabot, Ara Schorscher-Petcu, Yinguo Hong, Zhiyong Wang, Remi Quirion
Pages 151-171
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- Christopher A. Salvatore, Stefanie A. Kane
Pages 185-197
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- P.J. Wookey, A. Zulli, C. Lo, D. L. Hare, A. P. Schwarer, I. A. Darby et al.
Pages 199-233
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About this book
In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.
Editors and Affiliations
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School of Biological Sciences, University of Auckland, Auckland , New Zealand
Deborah L. Hay
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University of Auckland, Auckland, New Zealand
Ian M. Dickerson