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Rabbit Biotechnology

Rabbit genomics, transgenesis, cloning and models

  • Book
  • © 2009

Overview

Editors:
  1. Louis-Marie Houdebine

    1. Institute of Research in Agronomy, Jouy en Josas, France

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  2. Jianglin Fan

    1. Department of Molecular Pathology, Interdisciplinary Graduate, School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

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    You can also search for this editor in PubMed   Google Scholar

  • It is clear that with the progress of genome sequencing, ES cells culture, cloning, transgenesis and interfering RNAs and other techniques, rabbit biotechnology is entering a new era.
  • It is a good time to emphasize this fact by the publication of this book

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
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  2. Introduction

    • Louis-Marie Houdebine, Jianglin Fan
    Pages 1-2

  3. Improvement of Rabbit Production

    • Shuji Kitajima
    Pages 3-12

  4. Basic Methods for Experimental Rabbits

    • Kazutoshi Nishijima
    Pages 13-22

  5. Useful Information for Rabbit Genes, Proteins, and Antibodies

    • Tomonari Koike, Jifeng Zhang, Jianglin Fan
    Pages 23-26

  6. General Physiology of Rabbits

    • Masashi Morimoto
    Pages 27-35

  7. Rabbit Transgenesis

    • Shuji Kitajima, Enqi Liu, Jianglin Fan
    Pages 37-47

  8. Rabbit as a Model for the Study of Human Diseases

    • Masashi Shiomi
    Pages 49-63

  9. Transgenic Rabbits to Prepare Pharmaceutical Proteins

    • Louis-Marie Houdebine, Geneviève Jolivet, Pierre-Jean Ripoll
    Pages 65-75

  10. Derivation and Characterization of Rabbit Embryonic Stem Cells: A Review

    • Elen Gócza, Zsuzsanna BÅ‘sze
    Pages 77-104

  11. Rabbit Cloning

    • Andras Dinnyes, Zsuzsanna Polgar, Qinggang Meng
    Pages 105-128

  12. The European Rabbit Genome

    • Jessica Alföldi, Federica Di Palma, Kerstin Lindblad-Toh
    Pages 129-129

  13. Back Matter

    Pages 131-132
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Keywords

About this book

Louis-Marie Houdebine and Jianglin Fan The study of biological functions of proteins and their possible roles in the pathogenesis of human diseases requires more and more relevant animal m- els. Although mice including genetically modified mice offer many possibilities, other non-murine species are absolutely required in some circumstances. Rabbit is one of these species, which has been widely used in biomedical studies. This animal is genetically and physiologically closer to humans including cardiov- cular system and metabolism characteristics. Rabbit is thus more appropriate than mice to study some diseases such as atherosclerosis and lipid metabolism. Because of its larger size, surgery manipulation, bleeding, and turn-over studies are much easier performed in rabbits than in mice. Furthermore, transgenic rabbits can be produced using microinjection and other methods such as lentiviral v- tors. Cloning in rabbits has been proved possible, even though still laborious and time-consuming. Hopefully, functional rabbit ES cell lines will be available in the coming years. Gene deletion or knock-out in rabbits will then become possible.

Editors and Affiliations

  • Institute of Research in Agronomy, Jouy en Josas, France

    Louis-Marie Houdebine

  • Department of Molecular Pathology, Interdisciplinary Graduate, School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan

    Jianglin Fan

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