Current Treatment of Retroperitoneal Sarcomas

1. Front Matter

   Pages i-xiv

   PDF

2. History of Surgery in Retroperitoneal Sarcomas

   • Vittorio Quagliuolo, Laura Ruspi, Ferdinando C. M. Cananzi, Alessandro Gronchi

   Pages 1-7

3. The Pathology of Retroperitoneal Sarcomas

   • Marta Sbaraglia, Piergiuseppe Colombo, Angelo Paolo Dei Tos

   Pages 9-19

4. The Complex Nature of Soft Tissue Sarcomas, Including Retroperitoneal Sarcomas

   • Fabio Grizzi, Elena Monica Borroni, Dorina Qehajaj, Sanja Stifter, Maurizio Chiriva-Internati, Ferdinando C. M. Cananzi

   Pages 21-32

5. Imaging of Retroperitoneal Sarcomas

   • Luca Balzarini, Nicolò Gennaro, Carlo Morosi

   Pages 33-48

6. Current Principles of Surgical Management of Retroperitoneal Sarcomas

   • Marco Fiore, Sergio Sandrucci

   Pages 49-60

7. Managing Early and Late Postoperative Complications

   • Stefano Radaelli, Sergio Valeri

   Pages 61-75

8. Major Vascular Resection in Retroperitoneal Surgery

   • Ferdinando C. M. Cananzi, Laura Ruspi, Jacopo Galvanin, Vittorio Quagliuolo

   Pages 77-92

9. Pattern and Management of Recurrent Retroperitoneal Liposarcoma

   • Elisabetta Pennacchioli, Massimo Barberis, Stefania Rizzo

   Pages 93-108

10. Management of Other Recurrent Retroperitoneal Sarcomas

    • Marco Rastrelli, Saveria Tropea, Carlo Riccardo Rossi

    Pages 109-119

11. The Role of Radiation Therapy in the Treatment of Retroperitoneal Sarcomas

    • Antonino De Paoli, Federico Navarria, Elisa Palazzari, Piera Navarria, Claudia Sangalli

    Pages 121-131

12. Medical Therapy in Retroperitoneal Sarcomas

    • Giovanni Grignani, Roberta Sanfilippo, Alexia F. Bertuzzi

    Pages 133-141

13. Predicting the Risk of Recurrence in Retroperitoneal Sarcoma

    • Dario Callegaro, Alessandro Gronchi, Andrea Napolitano, Bruno Vincenzi

    Pages 143-153

14. Multimodal Management of Metastatic Disease

    • Alexia F. Bertuzzi, Umberto Cariboni, Matteo M. Cimino, Guido Torzilli

    Pages 155-164

15. Postoperative Surveillance in Retroperitoneal Sarcomas

    • Alessandro Comandone, Antonella Boglione, Teresa Mele

    Pages 165-171

16. Towards a Global Collaboration: the Trans-Atlantic Retroperitoneal Sarcoma Working Group

    • Alessandro Gronchi, Vittorio Quagliuolo

    Pages 173-178

This book provides a comprehensive overview of the approach to retroperitoneal sarcomas, rare and challenging tumors requiring highly specialized, multidisciplinary management. Based on an updated review of the literature and drawing on the expertise of respected authors, it analyzes key topics – such as pre-operative work-up and staging, multimodal therapy, multi-organ resection, surgical complications and management of local recurrence and advanced disease – as well as several other debated issues.

Presenting surgery as the cornerstone in the treatment of this disease, the book serves both as a guide for non-expert physicians wishing to understand the best management of RPS patients, including the need to refer them to specialized centers, and as a state-of-the-art overview for surgeons with interest in sarcoma surgery.

• retroperitoneum
• mesenchymal tumors
• tumor markers
• biopsy
• radiotherapy in sarcomas
• TARPSWG
• patient advocay groups
• surgical oncology
• abdominal surgery
• Radiaton Oncology

• Surgical Oncology Unit, Department of Surgery, Humanitas Clinical and Research Center, Rozzano, Milan, Italy

  Vittorio Quagliuolo

• Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

  Alessandro Gronchi

Vittorio Quagliuolo specialized in surgery of the digestive tract and in clinical oncology at the University of Milan. He started his career at the Istituto Nazionale dei Tumori in Milan under the direction of Prof Umberto Veronesi and mentored by Prof Leandro Gennari. His interests focused on tumors of the low rectum, hepatic metastases, and on the surgical treatment of sarcomas of the limbs, trunk and retroperitoneum, in particular on the conservative surgery of mesenchymal tumors. Since 1997 he has worked at the Humanitas Cancer Center – from 2001 to 2010 as Chief of the Sarcoma Unit and since 2011 as Director of the Division of Surgical Oncology.
He is a founding member of the European Society of Mastology (EUSOMA) and the Italian Sarcoma Group (ISG) and member of the Trans-Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG). He has participated in several surgical trials of the ISG and is currently involved in the European Organization for Research and Treatment ofCancer’s STRASS trial investigating neoadivant radiotherapy in retroperitoneal sarcomas.

Alessandro Gronchi received his medical degree (high honors) in 1992 and board certification in General Surgery in 1997 from Milan University. He did a fellowship in Surgical Oncology at the National Cancer Institute – Milan – Italy in 1998. He has been chair of the Sarcoma Service at the National Cancer Institute – Milan – Italy since 2001. He has a life-time professional dedication to soft tissue sarcomas (STS), desmoid-type fibromatosis (DF) and gastrointestinal stromal tumors (GIST).
He serves as chair of the STS committee of the Italian Sarcoma Group (ISG), past-chair of the EORTC-STBSG, past president of the Connective Tissue Oncology Society (CTOS) 2017, President Elect of the Italian Society of Surgical Oncology (SICO), member of the Sarcoma Disease Site Working Group of the Society of Surgical Oncology (SSO) 2018-2021; he is member of the European Society for Medical Oncology (ESMO), the European Society of Surgical Oncology (ESSO), the European Surgical Association (ESA) the American Society of Clinical Oncology (ASCO), and honorary member of the Polish Society of Surgical Oncology (PSSO). He is one of the initiators of the Trans-Atlantic RetroPeritoneal Sarcoma Working Group (TARPSWG). He has authored more than 300 scientific publications, serves as Associate Editor of the Sarcoma Journal, Journal of Surgical Oncology and Annals of Surgical Oncology.

Policies and ethics