Advances in the Immunopathogenesis of Multiple Sclerosis

1. Front Matter

   Pages I-XI

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2. Introduction

   • P. A. Muraro, A. Lugaresi, D. Gambi

   Pages 1-2

3. The affinity spectrum of myelin basic protein-reactive T cells

   • B. Mazzanti, E. Traggiai, B. Hemmer, R. Martin, L. Massacesi, M. Vergelli

   Pages 3-9

4. The naïve and memory MBP-reactive CD4+ T cell repertoire: implications for the autoimmune concept in multiple sclerosis

   • P. A. Muraro, B. Bielekova

   Pages 11-19

5. From specificity to degeneracy to molecular mimicry: antigen recognition of human autoreactive and pathogen-specific CD4+ T cells

   • B. Hemmer, C. Pinilla, B. Gran, H. F. McFarland, R. Houghten, R. Martin

   Pages 21-28

6. Immune activation in the interface between innate immunity and adaptive response:in vitro studies and therapeutical implications

   • G. Ristori, A. Perna, C. Montesperelli, L. Battistini, R. Bomprezzi, S. Cannoni et al.

   Pages 29-35

7. Neuronal control of the immunological microenvironment in the CNS: implications on neuronal cell death and survival

   • H. Neumann, T. Misgeld, I. Medana

   Pages 37-47

8. Levels of platelet-activating factor in cerebrospinal fluid and plasma of patients with relapsing-remitting multiple sclerosis

   • M. Arese, L. Callea, C. Ferrandi, F. Bussolino

   Pages 49-57

9. The contribution of magnetic resonance imaging to the understanding of multiple sclerosis pathogenesis

   • M. Rovaris, G. Iannucci, M. Filippi

   Pages 59-66

10. The role of proinflammatory cytokines in multiple sclerosis

    • R. Furlan, P. L. Poliani, A. Bergami, M. Gironi, G. Desina, G. Martino

    Pages 67-77

11. Experimental autoimmune encephalomyelitis in the common marmoset Callithrix jacchus

    • A. Uccelli, G. L. Mancardi, D. Giunti, H. Brok, L. Roccatagliata, E. Capello et al.

    Pages 79-84

12. Back Matter

    Pages 85-86

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P.A. MURARO, A. LUGARESI, D. GAMBI Many of the pathological aspects of multiple sclerosis (MS) lesions have been known for over a century. It is only recently, however, that different patterns of demyelination have been linked to distinct pathways of immune-mediated tissue destruction. In particular, the inter-individual heterogeneity of MS lesions has suggested that different mechanisms may act in different patients, accounting for the variability observed in clinical course, immunological findings in peripheral blood and cere­ brospinal fluid (CSF), and response to immunomodulatory treatments. To provide an overview of the basic mechanisms possibly involved in MS lesion initiation and development, an international meeting was organized in the context of the annual Congress of the Italian Neuroimmunology Association (AINI), held at the University of Chieti, in Chieti Italy on 29 October 1998. The high standard of presentations prompted us to report them in extended form, to highlight recent pro­ gress in the understanding of basic mechanisms sustaining MS immuno­ pathogenesis. A central role in the possible mechanisms leading to myelin destruc­ tion has been attributed to T lymphocytes reactive to myelin antigens. Studies on the myelin antigen-specific T cell repertoire have contributed significant advances to our knowledge of autoimmunity (Chapters 1,2).

• Antigen
• Nervous System
• T cell
• antigen presentation
• brain
• cognition
• cytokine
• innate immunity
• magnetic resonance
• magnetic resonance imaging
• magnetic resonance imaging (MRI)
• pathogenesis
• pathophysiology
• physiology

• Department of Oncology and Neuroscience, Medical School, University G. D’Annunzio, Chieti, Italy

  D. Gambi, P. A. Muraro, A. Lugaresi

• Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, USA

  P. A. Muraro

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