Sepsis and Organ Dysfunction

1. Front Matter

   Pages I-XVI

   PDF

2. Introductory Remarks

   1. Front Matter

      Pages 17-17

      PDF

   2. Sepsis and Organ Dysfunction — Basics, Controversies, Rationale

      • A. E. Baue

      Pages 19-34

3. Sepsis and Organ Dysfunction: From Chaos to Rationale

   1. Front Matter

      Pages 35-35

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   2. Alveolar Epithelium in Host Defence: Cytokine Production

      • M. Liu

      Pages 37-50

   3. Phagocytosis and Lung Injury

      • J. W. Booth

      Pages 51-57

   4. Dual Role of Neutrophil α-Defensins in Lung Inflammation

      • H. Zhang

      Pages 59-65

   5. Epithelial Injury in Sepsis and ARDS: Role of Leukocyte-Derived Proteases

      • H. Ginzberg, C. Chung-Wai, G. P. Downey

      Pages 67-76

   6. Pro- and Anti-inflammatory Cytokines and Apoptosis in Acute Lung Injury

      • S. Uhlig, D. Burdon

      Pages 77-93

   7. The Role of Interleukin-10 During Systemic Inflammation and Bacterial Infection

      • F. N. Lauw, S. J. H. van Deventer, T. van der Poll

      Pages 95-102

   8. Cardiovascular Surgery. Modulation of the Inflammatory Reaction

      • P. Giomarelli, S. Scolletta, E. Borelli

      Pages 103-110

   9. Microcirculation in Critical Illness

      • D. De Backer, M.-J. Dubois, J. Creteur

      Pages 111-119

   10. Microbial Translocation: from Myth to Mechanism

       • J. C. Marshall

       Pages 121-129

   11. Empirical Antibiotic Treatment in ICU Patients

       • P. Grossi

       Pages 131-139

   12. Rotation of Antibiotics — A New Strategy for Prescription in the Intensive Care Unit

       • D. Gruson, G. Hilbert

       Pages 141-150

   13. Diagnostic Approach to Sepsis — State of the Art

       • F. M. Brunkhorst, K. Reinhart

       Pages 151-167

   14. Septic Shock Therapy

       • R. Fumagalli, D. Codazzi, S. Cattaneo

       Pages 169-175

   15. Sepsis Trials in Children

       • G. Zobel

       Pages 177-188

   16. Sepsis and Clinical Trials: a New Era in Anti-Sepsis Therapies

       • J.-L. Vincent

       Pages 189-196

   17. Evolving Concepts and Challenges in Sepsis and MODS

       • A. Gullo

       Pages 197-214

Even if in the last years more information on sepsis and new treatments has become available, mortality rate is however high. In fact, the complexity of the several biohumoral factors involved in this process is difficult to understand. Another major problem is the consequent organ failure, which grows in a sequential way and in relation with the lesion gravity and the functional reserves of the patient. The volume presents the most recent results of research in this field.

• Immune system
• Sepsis
• antibiotics
• bacteria
• bacterial infection
• bacterial translation
• endotoxin
• infection
• organ dysfunction
• infectious diseases

• Department of Surgery, S. Louis University, School of Medicine, Fishers Island, USA

  A. E. Baue

• Department of Clinical Sciences, Section of Anaesthesia, Intensive Care and Pain Clinic, Trieste University Medical School, Trieste, Italy

  G. Berlot, A. Gullo

• Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium

  J.-L. Vincent

• Trieste, Italy

  Organ Failure Academy

Policies and ethics