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Ultrasound contrast agents

Targeting and processing methods for theranostics

  • Book
  • © 2010

Overview

Editors:
  1. Gaio Paradossi

    1. Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Rome, Italy

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  2. Paolo Pellegretti

    1. Esaote — R & D Ultrasuoni, Genoa, Italy

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  3. Andrea Trucco

    1. Acoustics, Antenna Arrays, and Underwater Signals Lab. Dept. of Biophysical and Electronic Engineering (DIBE), University of Genoa, Genoa, Italy

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-XIII
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  2. Towards Ultrasound Molecular Imaging

    • Vincenzo Lionetti, Sergio Paddeu
    Pages 1-11

  3. Use of Microbubbles as Ultrasound Contrast Agents for Molecular Imaging

    • Mathieu Hauwel, Thierry Bettinger, Eric Allémann
    Pages 13-23

  4. Design of Novel Polymer Shelled Ultrasound Contrast Agents: Towards an Ultrasound Triggered Drug Delivery

    • Mariarosaria Tortora, Letizia Oddo, Silvia Margheritelli, Gaio Paradossi
    Pages 25-39

  5. Lipidic Microbubble Targeting of Surface Proteins Using an in Vitro System

    • Ines Zerbe, Nenad Gajovic-Eichelmann
    Pages 41-52

  6. Protein Interactions with Microballoons: Consequences for Biocompatibility and Application as Contrast Agents

    • Johannes Stigler, Martin Lundqvist, Tommy Cedervall, Kenneth Dawson, Iseult Lynch
    Pages 53-66

  7. Polymer Based Biointerfaces: A Case Study on Devices for Theranostics and Tissue Engineering

    • Pamela Mozetic, Mariarosaria Tortora, Barbara Cerroni, Gaio Paradossi
    Pages 67-77

  8. Ultrasound Contrast Agent Microbubble Dynamics

    • Marlies Overvelde, Hendrik J. Vos, Nico de Jong, Michel Versluis
    Pages 79-97

  9. Characterization of Acoustic Properties of PVA-Shelled Ultrasound Contrast Agents

    • Dmitry Grishenkov, Claudio Pecorari, Torkel B. Brismar, Gaio Paradossi
    Pages 99-108

  10. Novel Characterization Techniques of Microballoons

    • Paulo Fernandes, Melanie Pretzl, Andreas Fery, George Tzvetkov, Rainer Fink
    Pages 109-127

  11. A Comparative Analysis of Contrast Enhanced Ultrasound Imaging Techniques

    • Andrea Trucco, Marco Crocco, Anastasis Kounoudes, Claudia Sciallero
    Pages 129-142

  12. Remote Measurement of the Ultrasound Contrast Agent Concentration

    • Marco Crocco, Claudia Sciallero, Andrea Trucco
    Pages 143-156

  13. Bubble Behavior Testing (BBT) System for Ultrasound Contrast Agent Characterization

    • Francesco Guidi, Riccardo Mori, Hendrik J. Vos, Piero Tortoli
    Pages 157-174

  14. A New Flexible Ultrasound Scanner Suitable for Research Topics

    • Alessandro Nencioni, Paolo Pellegretti
    Pages 175-188

  15. Back Matter

    Pages 189-193
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Keywords

About this book

Recent advancements in nano/micro materials and related characterization approaches allow the design of a new type of ultrasound contrast agents (UCAs) with enhanced multifunctional behaviour. This is chance is also supported by the recent achievements in modelling and signal processing. This book provides the state of art of the research activity of two successful European projects, TAMIRUT and SIGHT, addressing an integrated system, encompassing the contrast agent, the hardware equipment and the processing strategies, as a key tool for a combined diagnostic and therapeutic approaches (theranostics) in medical ultrasound. The work provides a highlight of the state of art in the research of novel ultrasound contrast agents (UCAs). Main progresses on the multifunctional aspects of next-generation UCAs concern targeting and drug release properties, perfusion and biointerface behaviour, ultrasound scattering performance, signal processing, electronic equipment.

Reviews

From the reviews: “Leading experts in this field present the latest research and knowledge within 13 chapters from the development of new echogenic injectable agents and devices to interactions with cells and tissues including the development of hard- and software for detecting and evaluating contrast agents - many prominent up-to-date items are covered by this book. … The book is dedicated to leaders with a background in theory who want to deepen their knowledge with up-to-date research results and are interested in ultrasound contrast agents’ future applications.” (Christian Kollmann, Ultraschall in der Medizin, Vol. 31, June, 2010)

Editors and Affiliations

  • Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Rome, Italy

    Gaio Paradossi

  • Esaote — R & D Ultrasuoni, Genoa, Italy

    Paolo Pellegretti

  • Acoustics, Antenna Arrays, and Underwater Signals Lab. Dept. of Biophysical and Electronic Engineering (DIBE), University of Genoa, Genoa, Italy

    Andrea Trucco

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