Multiple Primary Malignancies

1. Front Matter

   Pages I-XXII

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2. Nosography

   • Andrea Renda, Nicola Carlomagno

   Pages 1-6

3. Epidemiology: Data from Cancer Registries

   • Maurizio Montella, Carlotta Buzzoni, Anna Crispo

   Pages 7-26

4. Bioinformatics in MPM: Using Decision Trees To Predict a Second Tumor Site

   • Alberto Cavallo, Concetta Dodaro

   Pages 27-50

5. Carcinogenesis

   • Nicola Carlomagno, Francesca Duraturo, Gennaro Rizzo, Cristiano Cremone, Paola Izzo, Andrea Renda

   Pages 51-61

6. Iatrogenic Second Tumors

   • Pietro Lombari, Loredana Vecchione, Antonio Farella, Sebastiano Grassia, Fernando De Vita, Giuseppe Catalano et al.

   Pages 63-81

7. Immunodeficiency and Multiple Primary Malignancies

   • Michele Santangelo, Sergio Spiezia, Marco Clemente, Andrea Renda, Arturo Genovese, Giuseppe Spadaro et al.

   Pages 83-96

8. Multiple Primary Malignancies and Human Papilloma Virus Infections

   • Stefania Staibano, Massimo Mascolo, Lorenzo Lo Muzio, Gennaro Ilardi, Loredana Nugnes, Concetta Dodaro et al.

   Pages 97-105

9. The Hereditary Syndromes

   • Nicola Carlomagno, Luigi Pelosio, Akbar Jamshidi, Marius Yabi, Francesca Duraturo, Paola Izzo et al.

   Pages 107-128

10. Multifocal and Multicentric Tumors

    • Carlo de Werra, Ivana Donzelli, Mario Perone, Rosa Di Micco, Gianclaudio Orabona

    Pages 129-142

11. The Cancer Spectrum Related to Hereditary and Familial Breast and Ovarian Cancers

    • Matilde Pensabene, Rosaria Gesuita, Ida Capuano, Caterina Condello, Ilaria Spagnoletti, Eleonora De Maio et al.

    Pages 143-155

12. The Role of Genetic Predisposition and Environmental Factors in the Occurrence of Multiple Different Solid Tumors. The Experience of the University Hospital of Sienna

    • Francesco Cetta, Armand Dhamo, Annamaria Azzarà, Laura Moltoni

    Pages 157-178

13. “Sporadic” Colorectal Tumors in Multiple Primary Malignancies

    • Concetta Dodaro, Enrico Russo, Giuseppe Spinosa, Luigi Ricciardelli, Andrea Renda

    Pages 179-194

14. Multiple Primary Malignancies: “Non-codified” Associations

    • Alessandro Scotti, Alessandro Borrelli, Gioacchino Tedesco, Francesca Di Capua, Cristiano Cremone, Michele Giuseppe Iovino et al.

    Pages 195-210

15. Laboratory for Patients at Risk of Multiple Primary Malignancies

    • Marcello Caggiano, Angela Mariano, Massimiliano Zuccaro, Sergio Spiezia, Marco Clemente, Vincenzo Macchia

    Pages 211-220

16. Multiple Primary Malignancies: Role of Advanced Endoscopy To Identify Synchronous and Metachronous Tumors of the Digestive Tract

    • Giuseppe Galloro, Luca Magno, Giorgio Diamantis, Antonio Pastore, Simona Ruggiero, Salvatore Gargiulo et al.

    Pages 221-230

17. Diagnostic Imaging Techniques for Synchronous Multiple Tumors

    • Vincenzo Tammaro, Sergio Spiezia, Salvatore D’Angelo, Simone Maurea, Giovanna Ciolli, Marco Salvatore

    Pages 231-244

18. “DNA-Guided” Therapy

    • Nicola Carlomagno, Luigi Pelosio, Akbar Jamshidi, Francesca Duraturo, Paola Izzo, Andrea Renda

    Pages 245-266

19. Chemoprevention

    • Pietro Lombari, Gaetano Aurilio, Fernando De Vita, Giuseppe Catalano

    Pages 267-279

20. Conclusions

    • Andrea Renda

    Pages 281-284

In 2006, when my colleague Andrea Renda proposed multiple primary malignancies (MPM) as the subject of the Biennial Report to the 2008 Congress of the Italian - ciety of Surgery, I, together with the Steering Committee, quickly agreed. Recent progress in our understanding of the etiopathology of these neoplasms has led to - novative and significant progress on the clinical level. Importantly, the incidence of the onset of two or more tumors in the same patient suggests a more than casual - lationship. Furthermore, the occurrence of MPM derives from several different me- anisms—viral, iatrogenic, immunologic, environmental, and hereditary—such that any form of treatment must take into account the etiology of these tumors. After an epidemiological introduction, this monograph analyzes various aspects of multitumoral syndromes based on the experience of the Department of Surgical Sciences, along with that of other clinical departments of the University Federico II of Naples. In the discussion of inherited tumors, reference is made to the series of patients treated at the Department of Surgery at the University of Siena. The many topics that comprise this volume range from carcinogenesis to diagnostic strategies, and from epidemiology to innovations in imaging and endoscopic techniques. Among the clinical aspects, particular emphasis is given to sporadic and hereditary syndromes, as these patients are frequently treated by general surgery departments.

• Tumour
• classification
• endoscopy
• epidemiology
• genetic
• imaging
• imaging techniques
• surgery
• therapy
• abdominal surgery

From the reviews:

"This volume … focus casual associations rather than chance in multiple primary malignancies. … Practitioners and researchers in surgery, oncology, and allied fields are the intended audience. … It will be of most interest to those with a research or clinical interest in multiple primary tumors occurring through circumstance … rather than chance. … This is an excellent reference with particular strength in the area of hereditary syndromes. … Other workers in the field will find it of interest." (Carol Scott-Conner, Doody’s Review Service, July, 2009)

• Surgical, Anesthesiology-rianimative and Emergency Sciences Department, Federico II University, Naples, Italy

  Andrea Renda

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