Sepsis and Organ Dysfunction

1. Front Matter

   Pages I-XII

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2. Epidemiology and Clinical Course of Sepsis and MODS

   1. Front Matter

      Pages 13-13

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   2. Epidemiology and Clinical Course of Sepsis

      • L. Ilkka, J. Takala

      Pages 15-21

   3. The Complexities of Sepsis and Organ Dysfunction

      • A. E. Baue

      Pages 23-31

3. Scoring Systems

   1. Front Matter

      Pages 33-33

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   2. An Overview to Introduce Prognostic Indexes in MODS

      • A. E. Baue

      Pages 35-44

   3. Multiple Organ Dysfunction (MOD) Score

      • J. C. Marshall

      Pages 45-51

   4. The Logistic Organ Dysfunction (LOD) System

      • J. R. Le Gall, J. Klar, S. Lemeshow

      Pages 53-64

   5. Will the Use of Scores Benefit the Individual Patient and Improve Therapy?

      • R. Lefering, R. J. A. Goris

      Pages 65-69

4. Mediators and Prostaglandins

   1. Front Matter

      Pages 71-71

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   2. Old and New Mediators in Sepsis The Enigma Is Not Yet Resolved

      • M. Antonelli, M. Passariello

      Pages 73-80

   3. Modulating Prostaglandin Metabolism in Sepsis

      • M. R. Pinsky

      Pages 81-88

5. DO2/ $$ \mathop \text{V}\limits^\text{.} $$ O2 in Sepsis

   1. Front Matter

      Pages 89-89

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   2. Oxygen Delivery and Consumption Relationships in Sepsis — The Role of Inotropic and Vasoactive Drugs

      • O. Boyd

      Pages 91-96

6. Coagulation

   1. Front Matter

      Pages 97-97

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   2. Disturbances and Modulators of Coagulation and Fibrinolysis in Sepsis

      • L. G. Thijs

      Pages 99-111

7. Experimental and Clinical Approach

   1. Front Matter

      Pages 113-113

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   2. Therapies Directed against TNF-α and IL-1 during Sepsis

      • K. Reinhart, W. Karzai

      Pages 115-121

   3. Effects of Adrenergic Agents on the Hepato-Splanchnic Circulation: An Update

      • D. De Backer, J.-L. Vincent

      Pages 123-130

   4. When to Operate or to Stop Operating and to Plan a Reoperation

      • A. E. Baue

      Pages 131-144

Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism's homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and critical conditions. This objective represents a true challenge at the dawn of the XXI century.

• Anaesthesiologists
• Physicians
• circulation
• epidemiology
• metabolism
• pathophysiology
• physiology
• prevention

• Department of Surgery, Saint Louis University, Health Sciences Center, St. Louis, USA

  A. E. Baue

• Department of Anaesthesia, Intensive Care and Pain Therapy, University of Trieste, Cattinara Hospital, Trieste, Italy

  G. Berlot, A. Gullo

Policies and ethics