The Uveitis Atlas

1. Front Matter

   Pages i-xxx

   PDF

2. Normal Anatomy of the Uvea

   1. Front Matter

      Pages 1-1

      PDF

   2. Normal Histology of the Uvea

      • Michael Stuntz, Aniruddha Agarwal, Gerald Christensen, Quan Dong Nguyen

      Pages 3-6

   3. Normal Fundus

      • Sameeksha Tadepalli, Aniruddha Agarwal, Mohit Dogra, Vishali Gupta

      Pages 7-9

   4. Normal Fundus Fluorescein Angiography

      • Sana Khochtali, Imen Khairallah-Ksiaa, Salim Ben Yahia

      Pages 11-16

   5. Normal Indocyanine Green Angiography

      • Atul Arora, Aniruddha Agarwal, Vishali Gupta

      Pages 17-20

   6. Normal OCT and OCT Angiography of Retina and Choroid

      • Igor Kozak, Aniruddha Agarwal

      Pages 21-25

   7. Ocular Ultrasound and its Clinical Applications

      • Savleen Kaur, Ramandeep Singh

      Pages 27-35

   8. Ultrasound Biomicroscopy and its Clinical Applications

      • Savleen Kaur, Ramandeep Singh

      Pages 37-44

   9. Grades of Vitreous Clarity

      • Brian Madow, John H. Kempen

      Pages 45-50

3. Algorithms and Differential Diagnosis of Uveitis

   1. Front Matter

      Pages 51-51

      PDF

   2. Anterior Uveitis: Differential Diagnosis

      • Aniruddha Agarwal, Kanika Aggarwal, Aman Kumar, Vishali Gupta

      Pages 53-61

   3. Differential Diagnosis of Hypopyon Uveitis

      • Aniruddha Agarwal, Ilaria Testi, Ankur Singh, Vishali Gupta

      Pages 63-70

   4. Algorithm for Work-Up of Episcleritis and Scleritis

      • Dinesh Visva Gunasekeran, Rupesh Agrawal

      Pages 71-74

   5. Entities That Can Present as IU/Vitritis

      • Tripti Chaudhary, Reema Bansal

      Pages 75-78

   6. Algorithm for Work-Up of Panuveitis

      • Luca Cimino

      Pages 79-100

   7. Algorithm for Workup of Retinal Vasculitis

      • Ahmed M. Abu El-Asrar

      Pages 101-104

   8. Differential Diagnosis of Choroiditis

      • Alessandro Invernizzi

      Pages 105-117

   9. Differential Diagnosis of Infectious Retinitis

      • André Luiz Land Curi

      Pages 119-121

   10. Differential Diagnosis of Noninfectious Retinitis

       • Sofia Androudi, Anna Dastiridou

       Pages 123-126

Uveitis comprises a group of intraocular diseases that poses a diagnostic challenge to the ophthalmologists of all subspecialties, including uveitis specialists. The morphological expression of the diseases may be characteristic at times, but it is challenging to detect and recognize subtle clinical clues that might indicate towards a particular etiology: infectious, non-infectious or masquerade. Ancillary investigations including fluorescein angiography, indocyanine green angiography, auto fluorescence imaging, ultrasound, ultrasound biomicroscopy, laser flaremeter and optical coherence tomography play a crucial role in reaching a specific diagnosis and require proper interpretation in context of each disease variety. In addition, the radiological imaging, systemic work-up and laboratory investigations aid in establishing the diagnosis. This is a first comprehensive atlas that compiles these varied findings in each type of uveitis. It describes all uveitic entities employing the aid of slit lamp and anterior segment photographs, fundus photographs, ancillary investigations where applicable and relevant laboratory and radiologic investigations. The case-based format sets out the context clearly to match the diagnostic findings with the treatment plan. Covered in 136 chapters and more than 1000 images, this atlas is an essential reference guide for all uveitis specialists and general ophthalmologists. Regular updates on new insights, techniques and treatments meet the point-of-need requirements of the busy readers looking for most current information.

• HIV-related eye
• Intraocular tuberculosis
• Intravitreal
• Masquerades
• Scleritis

• Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

  Vishali Gupta, Aniruddha Agarwal

• Spencer Center for Vision Research, Byers Eye Institute at Stanford University, Palo Alto, USA

  Quan Dong Nguyen

• Department of Ophthalmology, Pitié-Salpêtrière University Hospital Sorbonne University, Paris, France

  Phuc LeHoang

Dr. Vishali Gupta is a Professor of Ophthalmology in the Retina and Uveitis Services of Advanced Eye Center, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. She runs a busy uveitis clinic, where nearly 300 uveitis patients are examined per week. Her research interests include addressing the diagnostic challenges involving intraocular tuberculosis, application of molecular biology techniques to diagnose intraocular tuberculosis, describing the phenotypic expression of the disease and the management strategies. Dr. Gupta has over 194 indexed publications and authored more than 76 chapters and 3 books. She is a much sought-after international speaker and delivered several keynote lectures. Dr. Gupta is currently the Vice President of the Uveitis Society of India and the Principal Investigator of the Collaborative Ocular Tuberculosis Study Group (COTS) with over 25 international centers participating in the study.

 Dr. Quan Dong Nguyen, M.D., M.Sc., FAAO Born in Saigon, Vietnam, and immigrated to the United States in 1980, Dr. Quan Dong Nguyen is a Professor of Ophthalmology at the Byers Eye Institute, Stanford University School of Medicine. Dr. Nguyen received his baccalaureate from the Phillips Exeter Academy and his bachelor and master of science degrees simultaneously in Molecular Biophysics and Biochemistry from Yale University. Subsequently, he earned his medical degree at the University of Pennsylvania.

He completed an internship in Internal Medicine at the Massachusetts General Hospital and a residency in Ophthalmology at the Massachusetts Eye and Ear Infirmary, Harvard Medical School. Dr. Nguyen also completed fellowships in Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, Ocular Immunology at the Wilmer Eye Institute, and medical and surgical retina at the Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary.

After completing his education in 2001, Dr. Nguyen joined the faculty at the Wilmer Eye Institute, Johns Hopkins University, as Assistant Professor and then Associate Professor of Ophthalmology. In 2013, he was appointed as the McGaw Endowed Chair in Ophthalmology, Professor and Chair of the Department of Ophthalmology and the Inaugural Director of the Stanley M. Truhlsen Eye Institute, and Assistant Dean for Translational Research at the University of Nebraska Medical Center. In 2017, Dr. Nguyen was invited to join the faculty at Stanford University.

Professor Nguyen is known for his innovative work in early proof-of-concept, first-inhuman clinical trials to evaluate potential pharmacotherapeutic agents for retinal vascular and uveitic diseases.

 Dr. Phuc LeHoang, M.D., Ph.D. is Professor of Ophthalmology at La Pitie-Salpetriere Hospital, Sorbonne University (Paris, France). His ophthalmology residency in Paris was completed by a Master of Science in Biochemistry and an education at the Pasteur Institute leading to a Ph.D. in Immunology in 1979. He received his Doctor of Medicine in 1981. He was appointed as Professor of Ophthalmology in 1985 and thereafter spent a sabbatical as Visiting Scientist at the National Eye Institute (Bethesda, USA).

Dr. LeHoang has co-authored over 300 articles in peer-reviewed literature as well as numerous book chapters and co-edited a textbook on uveitis with Prof. Bahram Bodaghi. As an investigator on numerous projects dealing with research, medical, and surgical management of ocular inflammation, he has established an effective school in that field in France. He has participated in the organization of several international meetings, served as President of the International Ocular Inflammation Society from 2003 to 2011. Besides, he is serving as colonel (reserve) in the French army and received the Medal of Voluntary Military Services and the Medal of the National Defence. A Member of the French National Academy of Surgery, Dr. LeHoang has been awarded knighthood in the Order of the Academic Palms (Chevalier dans l’Ordre des Palmes Academiques) and in the highest Order of the French Republic (Chevalier dans l’Ordre de la Legion d’Honneur).

Dr. Aniruddha Agarwal is currently working as an Assistant Professor in the Retina and Uveitis services in the Department of Ophthalmology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. He completed his Clinical Research Fellowship (subspecialty of vitreoretina and uveitis) in the Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, Omaha, Nebraska, USA, between 2014 and 2016. He did his ophthalmology residency at PGIMER, Chandigarh, India. He is a recipient of prestigious awards, such as the Bayer Global Ophthalmology Association Project (GOAP) Fellowship, Carl Camras Best Researcher Award, J.M Pahwa Award by Vitreoretina Society of India (VRSI), Narsing Rao Award by Uveitis Society of India (USI), and the Carl Herbort Award by the USI. In 2015, he was felicitated by the Hon. Prime Minister of India for his excellent contribution. He has authored more than 150 publications and 36 book chapters. His areas of interest include uveitis as well as medical and surgical diseases of the retina. He is an expert in ocular imaging, and has been part of numerous international presentations and collaborations in that field.

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