Molecular Imaging for Integrated Medical Therapy and Drug Development

1. Front Matter

   Pages I-XXI

   PDF

2. Advances in Molecular Imaging

   1. Advances in Molecular Imaging

      • Nagara Tamaki, Yuji Kuge

      Pages 1-4

3. New Molecular Imaging and Image-Guided Radiotherapy

   1. Front Matter

      Pages 5-5

      PDF

   2. Hypoxia Imaging for Image-Guided Radiotherapy

      • Quynh-Thu Le, Billy W. Loo, Nancy Lee

      Pages 7-18

   3. Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy

      • Yuji Kuge, Songji Zhao, Toshiki Takei, Nagara Tamaki

      Pages 19-29

   4. Development of a Prototype 3D PET Scanner Using Semiconductor Detectors and Depth of Interaction Information

      • Yuichi Morimoto, Yuichirou Ueno, Shinichi Kojima, Wataru Takeuchi, Takafumi Ishitsu, Kazuki Matsuzaki et al.

      Pages 30-41

   5. A New PET Scanner with Semiconductor Detector Reveals Intratumoral Inhomogeneous Cell Activity with High Spatial and Energy Resolution

      • Tohru Shiga, Naoki Kubo, Yuichi Morimoto, Norio Katoh, Chietsugu Katoh, Yuichirou Ueno et al.

      Pages 42-51

   6. A New Positron Emission Tomography (PET) Scanner with Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients with Nasopharyngeal Carcinoma

      • Norio Katoh, Koichi Yasuda, Tohru Shiga, Masakaxu Hasegawa, Rikiya Onimaru, Shinichi Shimizu et al.

      Pages 52-59

   7. Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small-Animal Imaging

      • Keiichi Magota, Naoki Kubo, Kenji Narihiro, Kotaro Suzuki, Kenichi Nishijima, Songji Zhao et al.

      Pages 60-68

   8. Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-Annexin A5

      • Yan Zhao, Yuji Kuge, Songji Zhao, H. William Strauss, Francis G. Blankenberg, Nagara Tamaki

      Pages 69-77

   9. Quantification of Myocardial Blood Flow Using Rubidium-82 PET

      • Keiichiro Yoshinaga, Chietsugu Katoh, Osamu Manabe, Masanao Naya, Robert A. deKemp, Ran Klein et al.

      Pages 78-90

4. Molecular Imaging for Regenerative Treatment

   1. Front Matter

      Pages 91-91

      PDF

   2. New Concepts for Molecular and Functional Imaging of the Heart: Implications for Regenerative Treatments

      • Ignasi Carrió, Manel Ballester, Albert Flotats

      Pages 93-104

   3. Molecular Imaging of Angiogenesis

      • Ambros J. Beer, Hans-Jürgen Wester, Markus Schwaiger

      Pages 105-115

   4. Spontaneous In Vivo Regeneration of the Articular Cartilage Using a Novel Double-Network Hydrogel

      • Nobuto Kitamura, Kazunori Yasuda, Jian Ping Gong, Yoshihito Osada

      Pages 116-125

   5. Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders: Perspectives for Translational Research and Clinical Application

      • Satoshi Kuroda, Yuji Kuge, Nagara Tamaki, Yoshinobu Iwasaki

      Pages 126-138

   6. Noninvasive Optical Tracking of Bone Marrow Stromal Cells Transplanted into Rat Cerebral Infarct

      • Taku Sugiyama, Satoshi Kuroda, Toshiya Osanai, Katsuhiko Maruichi, Yasuhiro Chiba, Hideo Shichinohe et al.

      Pages 139-144

   7. Thermoreversible Gelation Polymer (TGP) Hydrogel as a Degradable Scaffold for Bone Marrow Stromal Cell Transplantation

      • Toshiya Osanai, Satoshi Kuroda, Hiroshi Yasuda, Yasuhiro Chiba, Katsuhiko Maruichi, Masaaki Hokari et al.

      Pages 145-151

   8. Beneficial Effects of Bone Marrow Stromal Cell Transplantation on Axonal Regeneration in Injured Spinal Cord

      • Yasuhiro Chiba, Satoshi Kuroda, Katsuhiko Maruichi, Toshiya Osanai, Masaaki Hokari, Shunsuke Yano et al.

      Pages 152-157

   9. Transplanted Bone Marrow Stromal Cells Improve Cognitive Function after Diffuse Axonal Injury in Rats

      • Katsuhiko Maruichi, Satoshi Kuroda, Yasuhiro Chiba, Toshiya Osanai, Taku Sugiyama, Masaaki Hokari et al.

      Pages 158-164

Molecular imaging plays an important role in drug discovery and advanced medical practice. A symposium of world leaders in drug research and development, molecular imaging, and medical therapy including regenerative treatment and radiation therapy has led to the publication of this book. Based on the proceedings of the symposium, many excellent ideas and valuable discussions are introduced that will guide the reader toward new advances in photon detection and protein modification as well as new developments in molecular imaging itself. Both protein modification and photon detection are emerging technologies that hold forth the promise of innovative strategies for drug discovery and medical care. The publication of these proceedings is a timely means of sharing significant experience and knowledge with many specialists all over the world. This book will be of great value to a wide variety of researchers in the fields of drug development and molecular imaging technologies, leading to integrated medical therapy and progress in human health.

• Integrated medical therapy.
• brain
• drug
• drug development
• drug discovery
• drug research
• imaging
• molecular imaging
• radiation
• radiotherapy
• research

From the reviews:

“The book is divided into 4 parts and 28 presentations, with multiple authors for each presentation, and an introductory overview by the editors on advances in molecular imaging. … This book is intended for researchers involved in molecular imaging or drug development and clinicians who treat patients with or without cancer. The material will be useful to individuals familiar with this discipline and those who are new to this discipline and will likely be involved with personalized medical care.” (Aurelio Matamoros, Jr., The Journal of Nuclear Medicine, Vol. 53 (7), July, 2012)

• Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

  Nagara Tamaki

• Department of Tracer Kinetics and Bioanalysis, Hokkaido University Graduate School of Medicine, Sapporo, Japan

  Yuji Kuge

Policies and ethics