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Medaka

A Model for Organogenesis, Human Disease, and Evolution

  • Book
  • © 2011

Overview

  • The first book to cover the expanding research on medaka

  • Describes recent progress in the field and provides a good introduction of this fish system along with information on the long history of medaka in Japanese culture and science

  • Biological and genome resources are listed with accessible web sites, especially helpful for new researchers in the field

  • Includes supplementary material: sn.pub/extras

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Table of contents (24 chapters)

  1. Genomics, Genetics, and Resources

  2. Organogenesis and Disease Models

  3. Germ Cells, Sex Determination, and Reproduction

About this book

Oryzias latipes, known as medaka, is a model organism from East Asia. Breeding of this small, egg-laying freshwater teleost fish has long been popular among hobbyists in Japan. Now, as biological science has entered the genome era, the medaka provides significant advantages that make it one of the most valuable vertebrate models: a large collection of spontaneous mutants collected over a century, the presence of highly polymorphic inbred lines established over decades, and a recently completed genome sequence. This book is the first comprehensive monograph to cover a variety of medaka research. It opens with a historical view of medaka, followed by a series of research topics in the four major areas where the medaka is increasingly important: genomics, genetics, and resources; organogenesis and disease models; germ cells, sex determination, and reproduction; and evolution. Readers will find state-of-the-art information on medaka genetics and genomics such as the first isolation of active transposons in vertebrates, the influence of chromatin structure on sequence variation, fine QTL analysis, and versatile mutants as human disease models.

Reviews

“In view of the abundance of the topics treated in this volume, the state-of-the-art information on Medaka genetics and genomics, the meaningful figures and diagrams (many are suitable for teachings), and the wealth of references, this volume is surely a ‘must’ for those working with this model organism, but it is also recommended to all researches interested in fish biology.” (Hartmut Greven, Bulletin of Fish Biology, Vol. 15, 2015)

Editors and Affiliations

  • Laboratory of Bioresources, National Institute for Basic Biology, Okazaki, Japan

    Kiyoshi Naruse

  • Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki, Japan

    Minoru Tanaka

  • Department of Biological Sciences Graduate School of Science, The University of Tokyo, Tokyo, Japan

    Hiroyuki Takeda

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