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  • Book
  • © 2011

Mechanosensing Biology

  • Most up-to-date information in the field of mechanobiology

  • Cutting-edge advancements in research into locomotor and circulatory diseases

  • Includes an exploration of mechanosensor nanoscience, gravity and tissues, and mechanobiology in space

  • Includes supplementary material: sn.pub/extras

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiii
  2. Cells and Signals

    1. Front Matter

      Pages 1-1
    2. Mechanobiology During Vertebrate Organ Development

      • Makoto Asashima, Yoshiro Nakajima, Yuzuru Ito, Tatsuo Michiue, Kiyoshi Ohnuma
      Pages 39-47
  3. Tissue and Gravity

    1. Front Matter

      Pages 49-49
    2. Mechanobiology in Space

      • Yuushi Okumura, Takeshi Nikawa
      Pages 63-70
    3. Mechanical Stress and Bone

      • Masaki Noda, Tadayoshi Hayata, Tetsuya Nakamoto, Takuya Notomi, Yoichi Ezura
      Pages 71-86
    4. TRP Channels and Mechanical Signals

      • Makoto Suzuki, Atsuko Mizuno
      Pages 87-101
  4. Skeletal Response

    1. Front Matter

      Pages 103-103
    2. Osteoblast Biology and Mechanosensing

      • Pierre J. Marie, Pierre J. Marie
      Pages 105-126
    3. Osteocyte Mechanosensation and Transduction

      • Lynda Faye Bonewald
      Pages 141-155
    4. Mechanosensing and Signaling Crosstalks

      • Toshio Matsumoto, Rika Kuriwaka-Kido, Shinsuke Kido
      Pages 157-166
    5. Osteoblast Development in Bone Loss Due to Skeletal Unloading

      • Akinori Sakai, Toshitaka Nakamura
      Pages 167-178
  5. Bone Signaling

    1. Front Matter

      Pages 179-179
    2. Osteoclast Biology and Mechanosensing

      • Géraldine Pawlak, Virginie Vives, Anne Blangy, Emmanuelle Planus, Corinne Albiges-Rizo
      Pages 193-213
  6. Back Matter

    Pages 215-219

About this book

Mechanical stress is vital to the functioning of the body, especially for tissues such as bone, muscle, heart, and vessels. It is well known that astronauts and bedridden patients suffer muscle and bone loss from lack of use. Even the heart, in pumping blood, causes mechanical stress to itself and to vascular tissue. With the loss of mechanical stress, homeostasis becomes impaired and leads to pathological conditions such as osteopenia, muscle atrophy, and vascular tissue dysfunction. In elderly populations, such mechanical pathophysiology, as well as the mechanical activities of locomotor and cardiovascular systems, is important because skeletal and heart functions decline and cause diseases in other organs. In this monograph, mechanical stress is discussed by experts in the field with respect to molecular, cellular, and tissue aspects in relation to medicine. Covering topics such as gravity and tissues and disuse osteoporosis, the book provides the most up-to-date information on cutting-edge advancements in the field of mechanobiology and is a timely contribution to research into locomotor and circulatory diseases that are major problems in contemporary society.

Editors and Affiliations

  • Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    Masaki Noda

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access