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New Trends in the Molecular and Biological Basis for Clinical Oncology

  • Conference proceedings
  • © 2009

Overview

Editors:
  1. Tetsuhiko Tachikawa

    1. Department of Oral Pathology and Diagnosis, Showa University School of Dentistry, Tokyo, Japan

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  2. Kiyoshi Nose

    1. Department of Microbiology, Showa University School of Pharmaceutical Sciences, Tokyo, Japan

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  3. Tohru Ohmori

    1. Institute of Molecular Oncology, Showa University, Tokyo, Japan

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  4. Mitsuru Adachi

    1. Division of Allergology and Respiratory Medicine, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (19 papers)

  1. Front Matter

    Pages I-XXIII
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  2. RTK-Related Signaling

    1. Front Matter

      Pages 1-1
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    2. HER2 Overexpression Attenuates the Antiproliferative Effect of Aromatase Inhibitor in MCF-7 Breast Cancer Cells Stably Expressing Aromatase

      • Incheol Shin, Todd Miller, E. Shizen Wang, Carlos L. Arteaga
      Pages 3-28

    3. Biomarker Research for Development of Molecular Target Agents

      • Kazuto Nishio, Tokuzo Arao
      Pages 29-36

    4. Epidermal Growth Factor (EGF) Receptor Kinase Activity is Required for Tumor Necrosis Factor (TNF)-α Mediated Intestinal Epithelial Survival

      • Toshimitsu Yamaoka, D. Brent Polk, Tohru Ohmori, Sojiro Kusumoto, Tomohide Sugiyama, Takao Shirai et al.
      Pages 37-54

    5. A Molecular Mechanism of Diminished Binding Activity between 15 bp Deletion Mutant EGFR and c-Cbl Ubiquitin Ligase

      • Tohru Ohmori, Takamichi Hosaka, Tomoko Kanome, Fumiko Inoue, Koichi Ando, Takashi Hirose et al.
      Pages 55-66

  3. Inflammation, Angiogenesis, and Tumor Progression

    1. Front Matter

      Pages 67-67
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    2. TGFβ-Mediated Epithelial Mesenchymal Transition and Metastasis in Skin and Head-and-Neck Cancer

      • Sophia Bornstein, Gang-Wen Han, Kristina Hoot, Shi-Long Lu, Xiao-Jing Wang
      Pages 69-80

    3. TGF-β and Tumor Progression Mediated by Reactive Oxygen Species

      • Kiyoshi Nose, Tadashi Sugimoto, Masami Wakamatsu, Fumihiro Ishikawa, Motoko Shibanuma
      Pages 81-85

    4. Role of MT1-MMP in Tumor-Stromal Interaction

      • Motoharu Seiki
      Pages 86-91

    5. Role of Proinflammatory Prostaglandin E2 in Bladder Tumor Progression

      • Shuntaro Hara
      Pages 92-95

  5. Poster Session

    1. Front Matter

      Pages 125-125
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    2. Drug Accumulation and Efflux Do not Contribute to Acquired Gefitinib Resistance

      • Sojiro Kusumoto, Tomohide Sugiyama, Masanao Nakashima, Toshimitsu Yamaoka, Takashi Hirose, Tsukasa Ohnishi et al.
      Pages 127-131

    3. Difference of EGFR-Binding Proteins between Wild Type and Mutant EGFR

      • Tsuyoki Kadofuku, Tomoko Kanome, Kazuto Nishio, Toshio Kuroki, Tohru Ohmori
      Pages 132-138

    4. Competitive Nuclear Export of Cyclin D1 and Hic-5 Regulates Anchorage-Dependence of Cell Growth and Survival

      • Kazunori Mori, Yukiko Oshima, Kiyoshi Nose, Motoko Shibanuma
      Pages 139-152
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Keywords

About this book

Newly developed molecular target anticancer drugs have shown remarkable efficacy even in the treatment of intractable cancers such as hepatoma and renal cell carcinoma. As cancer research is becoming a multidisciplinary endeavor, close cooperation across the basic, translational, and clinical research fields holds the promise of further advances in cancer therapeutics. This book sets forth new strategies for development: cancer therapy targeting receptor tyrosine kinases with clinical utilization of new signaling regulations; interaction between cancer progression and extracellular environments such as inflammatory cytokines and the extracellular matrix; and investigation of biomarkers for personalized cancer therapy, with microarray analysis and pharmacogenomics technology. These and other findings from the latest investigations into cancer cell biology and therapeutics make this book an invaluable source for investigators in both the clinical and basic cancer research fields.

Editors and Affiliations

  • Department of Oral Pathology and Diagnosis, Showa University School of Dentistry, Tokyo, Japan

    Tetsuhiko Tachikawa

  • Department of Microbiology, Showa University School of Pharmaceutical Sciences, Tokyo, Japan

    Kiyoshi Nose

  • Institute of Molecular Oncology, Showa University, Tokyo, Japan

    Tohru Ohmori

  • Division of Allergology and Respiratory Medicine, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan

    Mitsuru Adachi

Bibliographic Information

  • Book Title: New Trends in the Molecular and Biological Basis for Clinical Oncology

  • Editors: Tetsuhiko Tachikawa, Kiyoshi Nose, Tohru Ohmori, Mitsuru Adachi

  • DOI: https://doi.org/10.1007/978-4-431-88663-1

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Tokyo 2009

  • Hardcover ISBN: 978-4-431-88662-4Published: 23 December 2008

  • Softcover ISBN: 978-4-431-99864-8Published: 21 October 2010

  • eBook ISBN: 978-4-431-88663-1Published: 05 April 2009

  • Edition Number: 1

  • Number of Pages: XVIII, 192

  • Topics: Oncology

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