New Frontiers in Lifestyle-Related Diseases

1. Front Matter

   Pages I-XXII

   PDF

2. Regulation of Feeding and Energy Homeostasis in the Brain

   1. Front Matter

      Pages 1-1

      PDF

   2. Orphan Neuropeptides and the Regulation of Food Intake

      • Hiroshi Nagasaki, Yanling Xu, Yumiko Saito, Olivier Civelli

      Pages 3-19

   3. Neuronal Mechanisms of Feeding Regulation by Peptides

      • Masamitsu Nakazato, Hiroaki Ueno

      Pages 21-28

   4. Distribution and Localization of Galanin-like peptide (GALP) in Brain

      • Fumiko Takenoya, Haruaki Kageyama, Seiji Shioda

      Pages 29-38

   5. Functional Analysis of GALP in Feeding Regulation

      • Haruaki Kageyama, Koji Toshinai, Yukari Date, Masamitsu Nakazato, Fumiko Takenoya, Seiji Shioda

      Pages 39-45

   6. Regulation of Energy Homeostasis by GALP

      • Seiji Shioda, Haruaki Kageyama, Fumiko Takenoya, Yukari Date, Masamitsu Nakazato, Toshimasa Osaka et al.

      Pages 47-53

3. Lipid Metabolism and Atherosclerosis

   1. Front Matter

      Pages 55-55

      PDF

   2. Cholesterol Trafficking and Esterification With Relation to Atherosclerosis and Neurodegenerative Diseases

      • Ta-Yuan Chang, Catherine C. Y. Chang

      Pages 57-69

   3. Atherogenic Lipoproteins in Type 2 Diabetes with Nephropathy

      • Tsutomu Hirano

      Pages 71-76

   4. Regulatory mechanisms for cytosolic prostaglandin E synthase, cPGES/p23

      • Yoshihito Nakatani, Ichiro Kudo

      Pages 77-80

   5. Regulation of Intracellular Lipid Storage and Adipose Differentiation-Related Protein (ADRP)

      • Hiroyuki Itabe, Yutaka Masuda, Naoko Sasabe, Keiko Kitazato, Hiroyuki Arai, Tatsuya Takano

      Pages 81-88

   6. Roles of Vasoactive Agents in Macrophage Foam Cell Formation and Atherosclerosis

      • Takuya Watanabe, Akira Miyazaki

      Pages 89-96

4. Risk Factors for Cardiovascular Diseases

   1. Front Matter

      Pages 97-97

      PDF

   2. Sleep Apnea and Metabolic and Cardiovascular Complications

      • Christopher P. O’Donnell

      Pages 99-105

   3. Sleep Apnea Syndrome and Atherosclerosis

      • Kenji Minoguchi

      Pages 107-114

   4. Significance of Small Dense Low-Density Lipoproteins in Coronary Heart Disease

      • Shinji Koba, Tsutomu Hirano, Yuuya Yokota, Fumiyoshi Tsunoda, Yoshihisa Ban, Takayuki Sato et al.

      Pages 115-123

   5. Statin decreases IL-1 and LPS-induced inflammatory cytokines production in oral epithelial cells

      • Michihiko Usui, Reiko Suda, Yasushi Miyazawa, Makoto Kobayashi, Yoshimasa Okamatsu, Hisashi Takiguchi et al.

      Pages 125-131

5. Poster Sessions

   1. Front Matter

      Pages 133-133

      PDF

   2. Onco-suppressor p53 protein prevents an Alzheimer disease mouse model, Pin1-null mouse from the increase of presenilin-1

      • Katsuhiko Takahashi, Kiyoe Shimazaki, Takashi Obama, Rina Kato, Hiroyuki Itabe, Hirotada Akiyama et al.

      Pages 135-138

It is my great pleasure to publish New Frontiers in Lifestyle-Related Dis­ eases, the proceedings of the Showa University International Symposium for Life Sciences, 3rd Annual Meeting, held at Showa University on Sep­ tember 13, 2006. This symposium was supported, in part, by Grants for the Promotion of the Advancement of Education and Research in Graduate Schools and Ordinary Expenses for Private Schools from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. On behalf of Showa University, I would like to express my deepest thanks to all the authors and editors for their great contribution to the publication of this memorable book that accelerates research activity in lifestyle-related diseases. Akiyoshi Hosoyamada, M.D., Ph.D. President, Showa University Tokyo, Japan September 2007 v Preface The leading cause of death in Western countries and some developing countries is atherosclerotic cardiovascular diseases. Among them, acute myocardial infarction is the most common type of fatal disease, caused by the progression of atherosclerosis characterized by accumulation of choles­ terol in vascular walls. Development of atherosclerosis is greatly enhanced by major risk factors for cardiovascular diseases such as obesity, hyperlip­ idemia, diabetes (hyperglycemia), and hypertension. Among those, obesity frequently initiates a metabolic change that subsequently induces hyperlip­ idemia, diabetes, hypertension, and eventually atherosclerotic cardiovascu­ lar diseases. Because obesity and its related disorders largely depend on lifestyle factors such as high calorie intake and low physical activity, a series of disorders are termed lifestyle-related diseases.

• Atherosclerosis
• Coronary Heart Disease
• Diabetes
• Lifestyle-Related Diseases
• Lipid Metabolism
• Risk Factor
• homeostasis

From the reviews:

"This is a compilation of oral presentations and poster presentations conveying the latest information from basic and clinical research on lifestyle-related diseases. … This book is targeted at physicians, physicians in training, students, midlevels, and researchers who wish to understand the effects of disease-modifiable illnesses … . For bench and clinical researchers … this is an excellent book. It is especially helpful for those who wish to acquire a broader fund of knowledge about the mechanisms of atherosclerotic heart disease." (Dedric J Clarke, Doody’s Review Service, March, 2009)

• Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan

  Akira Miyazaki

• Second Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan

  Michio Imawari

Policies and ethics