Overview
- Editors:
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Seisuke Tanaka
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Kinki University School of Medicine, Osaka, Japan
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Chiaki Hamanishi
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Department of Orthopedic Surgery, Kinki University School of Medicine, Osaka, Japan
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Table of contents (21 papers)
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Mechanical Stress and Chondrocyte Reactions
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- Jill P. G. Urban, Robert J. Wilkins
Pages 3-20
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- Jyrki J. Parkkinen, Mikko J. Lammi, Matti O. Jortikka, Ritva I. Inkinen, Kai Kaarniranta, Heikki J. Helminen et al.
Pages 21-34
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- Kanji Fukuda, Shigeki Asada, Kazuhiro Otani, Chiaki Hamanishi, Seisuke Tanaka
Pages 35-47
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- Makoto Hashima, Chiaki Hamanishi, Seisuke Tanaka
Pages 48-55
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Functional Diagnosis of Osteoarthritis
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- Steven Treppo, Scott I. Berkenblit, David L. Bombard, Eliot H. Frank, Alan J. Grodzinsky
Pages 59-73
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- Jenny A. Tyler, Laurance D. Hall, Paul J. Watson
Pages 93-106
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- Toshikazu Kubo, Yuji Arai, Kappei Kobayashi, Jiro Imanishi, Masaharu Takigawa, Yasusuke Hirasawa
Pages 107-118
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New Cartilage Markers
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Front Matter
Pages 119-119
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- Johanne Martel Pelletier, Jean-Pierre Pelletier
Pages 121-133
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- Hiroshi Satsuma, Chiaki Hamanishi, Makoto Hashima, Seisuke Tanaka
Pages 142-150
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Promising Treatments 1
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Front Matter
Pages 151-151
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- S. W. Brostoff, D. J. Carlo, J. P. Diveley, E. E. Morgan, C. J. Nardo, S. P. Richieri et al.
Pages 153-162
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- Elizabeth O’Byrne, Vincent Blancuzzi, Hem Singh, Lawrence J. MacPherson, David T. Parker, E. Donald Roberts
Pages 163-173
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- Chiaki Hamanishi, Hiroshi Miyazaki, Hiroshi Satsuma, Seisuke Tanaka
Pages 174-184
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Promising Treatments 2: Cartilage Repair
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Front Matter
Pages 185-185
About this book
Basic research on osteoarthritis has been carried out mainly from the his tological and biochemical aspects of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical stress has been shown to be the principal factor in the initiation of osteoarthritis. Although the exact process by which mechanical stress leads to the total destruction of cartilage tissue remains unclear, several new research methods have enabled us to gain a deeper understanding of the process of degeneration. In October 1997, we organized an international symposium titled "Ad vances in Osteoarthritis" in Kobe, with the main topics being updated re search, diagnosis, and treatment of osteoarthritis. The proceedings of the symposium are presented here in five sections: (1) Mechanical stress and reactions of chondrocytes, such as intracellular ion changes, changes in the cytoskeleton, intracellular messenger systems, release of gas mediators, and changes in electromechanical properties of cartilage; (2) Functional diagnosis of osteoarthritis by MR imaging, and using calpain and collagenase III as new cartilage markers; (3) Treatment with a promising simple washout technique and IL-1RA and MMP antagonists; (4) Cartilage repair by new grafting tech niques; and (5) Problems following total joint replacement. We sincerely hope that the advanced knowledge provided in this volume of proceedings will be valuable to our readers.
Editors and Affiliations
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Kinki University School of Medicine, Osaka, Japan
Seisuke Tanaka
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Department of Orthopedic Surgery, Kinki University School of Medicine, Osaka, Japan
Chiaki Hamanishi