Protection Against Ischemia/Reperfusion Damage of the Heart

1. Front Matter

   Pages II-IX

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2. Modulators of Ischemia/Reperfusion Damage H+, Na+, and Ca2+

   1. Front Matter

      Pages 1-1

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3. Modulators of Ischemia/Reperfusion Damage H+, Na+, and Ca2+

   1. Regulatory Mechanism of NHE1 Isoform of Na+/H+ Exchanger in Cardiac and Other Tissues

      • Munekazu Shigekawa, Toshitaro Ikeda, Takahiro Iwamoto, Shigeo Wakabayashi

      Pages 3-21

   2. Role of the Vacuolar Proton Pump in Preconditioning

      • Roberta A. Gottlieb, Robert L. Engler

      Pages 23-37

   3. Role of the Na+/Ca2+ Exchanger in Intracellular Ca2+ Overload During Ischemia and Reperfusion

      • Shingo Seki, Seibu Mochizuki

      Pages 39-48

   4. The Role of Sodium—Hydrogen Exchange in the Ischemic and Reperfused Myocardium

      • Morris Karmazyn

      Pages 49-62

4. Modulators of Ischemia/Reperfusion Damage: Lipid Metabolites

   1. Front Matter

      Pages 63-63

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   2. Effects of Lysophosphoglycerides on KATP Channels in Cardiac Ventricular Cells: Blockage or Rundown?

      • Toshiaki Sato, Hideaki Ozaki, Makoto Arita

      Pages 65-73

   3. Lysophosphatidylcholine: A Possible Modulator of Ischemic Injury in the Heart

      • Hiroko Hashizume, Min Chen, Hong Ma, Nina Hoque, Akiyoshi Hara, Kazuto Yazawa et al.

      Pages 75-87

   4. Potential Role of Phospholipase A2 in the Normoxic, Ischemic, and Reperfused Heart

      • Ger J. Van der Vusse, Leon J. de Windt, Sylvia W. S. Jans, Robert S. Reneman, Marc van Bilsen

      Pages 89-114

   5. Effects of Lysophosphatidylcholine on Ion Transporters in the Heart

      • Haruaki Nakaya, Seiichi Yamaguchi, Ikumi Sakashita, Nobuyuki Nakajima

      Pages 115-127

5. Molecular Mechanisms of Myocardial and Vascular Remodeling in the Ischemic Heart

   1. Front Matter

      Pages 129-129

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   2. Molecular Mechanism of Cardiovascular Remodeling

      • Hideaki Kawaguchi, Akira Kitabatake

      Pages 131-145

   3. Osteopontin as a Coordinator of Stress-Induced Host Responses: Molecular Analysis of Its Interaction with Various Ligands

      • Toshimitsu Uede, Yohko Katagiri, Hiroshi Hotta, Kumiko Tanaka, Junko Iizuka

      Pages 147-156

   4. Coronary Reperfusion and Cytokines

      • Akira Matsumori, Koh Ono, Shigetake Sasayama

      Pages 157-177

   5. Brief Ischemia/Reperfusion Activates Transcellular Signaling Cascades and Leads to Proto-Oncogene Expression and Growth Factor Production

      • Patrik Htun, Miro Barancik, Wolfgang Schaper

      Pages 179-192

6. New Therapeutic Strategy to Attenuate Ischemia/Reperfusion Damage

   1. Front Matter

      Pages 193-193

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   2. Ischemia/Reperfusion Injury and Ion Channel Blockade

      • Satoshi Takeo, Kouichi Tanonaka, Jian-Xun Liu, Toru Kamiyama, Itaru Ohoi, Hiroshi Kajiwara et al.

      Pages 195-214

   3. Energy Ameliorants: A New Category of Antianginal Drugs

      • Kazuo Ichihara, Kumi Satoh, Tohru Nakai

      Pages 215-227

   4. Strategy Toward Warm Heart Cardioplegia: Our Experimental and Clinical Experience

      • Fumio Yamamoto, Junjiro Kobayashi, Hiroaki Sasaki, Yoshiaki Suematsu, Yutaka Hino, Jun Okawara et al.

      Pages 229-241

How to protect against ischemia/reperfusion damage is one of the most urgent problems in medicine. It is known that ischemic damage can be attenuated by improving the oxygen balance of the ischemic heart, but the damage-producing mechanism is not yet fully understood. This book provides the latest information on the pathophysiology of ischemia/reperfusion damage and presents new ideas for more effective methods for protection. In the first two sections, the roles of such factors as various ions and phospholipids that modulate ischemia/reperfusion damage are explored, providing a clear and updated explanation of the mechanisms involved. In the third section, the myocardial and vascular remodeling procedure in hearts that have undergone ischemia/reperfusion is explained in terms of signal transduction, enabling a new understanding of the remodeling process. In the final section, a new approach to protection against ischemia/reperfusion damage is presented.

• Drogen
• cardiovascular
• cytokine
• drugs
• growth factor
• heart
• lipide
• pathophysiology
• physiology

• Department of Pharmacology, Asahikawa Medical College, Asahikawa, Japan

  Yasushi Abiko

• Department of Pharmacology and Toxicology, The University of Western Ontario, London, Canada

  Morris Karmazyn

Policies and ethics