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Strategic Medical Science Against Brain Attack

  • Book
  • © 2002

Overview

Editors:
  1. Haruhiko Kikuchi

    1. National Cardio-Vascular Center, Suita, Osaka, Japan

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  • The most advanced research on building an effective defense system against brain attack that causes stroke

  • Possible approaches against brain attack are gathered in this book, including approaches through neuroregenesis, neuroprotection, enhanced neuro-tolerance, and brain imaging technology, which belong to the fields of medical sciences

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Table of contents (18 chapters)

  1. Front Matter

    Pages II-XIII
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  2. Strategies using neuritic reconstruction and neuroregeneration

    1. Front Matter

      Pages 1-1
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    2. Neural stem cells as a tool for cell transplantation

      • Jun Takahashi, Hiroki Toda, Nobuo Hashimoto
      Pages 3-20

    3. Repair of mammalian central nervous pathways: attempts to reconstruct normal neural connections with marked functional recovery

      • Saburo Kawaguchi, Takeshi Nishio
      Pages 21-27

  3. Strategies of neuroprotection

    1. Front Matter

      Pages 29-29
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    2. The MEK/ERK pathway as a target for stroke therapy

      • Shobu Namura, Alessandro Alessandrini
      Pages 31-44

    3. Redox regulation in neuronal damage during brain ischemia

      • Yasushi Takagi, Itaro Hattori, Kazuhiko Nozaki, Nobuo Hashimoto, Junji Yodoi
      Pages 45-56

    4. Structure and functions of pituitary adenylate cyclase activating polypeptide (PACAP) as a neurotrophic factor

      • Atsuro Miyata, Kenji Kangawa
      Pages 57-77

    5. Neurite outgrowth-promoting prostaglandins that act as neuroprotective agents against brain ischemia and may enhance recovery of higher neuronal functions

      • Takumi Satoh, Ryuzo Shingai, Kyoji Furuta, Masaaki Suzuki, Yasuyoshi Watanabe
      Pages 78-93

  4. Strategies using survival or death signals in neurons

    1. Front Matter

      Pages 95-95
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    2. Molecular mechanisms of neuronal survival; Roles of kinases in ischemic cell death

      • Yukiko Gotoh
      Pages 97-114

    3. Gene expression and manipulation in injured neurons

      • Hiroshi Kiyama, Sumiko Kiryu-Seo, Kazuhiko Namikawa
      Pages 115-124

  5. Strategies for and from cortical spreading depression

    1. Front Matter

      Pages 125-125
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    2. Brain ischemia and spreading depression in a primate model

      • Chiaki Yokota, Yuji Kuge, Masafumi Tagaya, Yasuhiro Hasegawa, Takeo Abumiya, Go Kito et al.
      Pages 127-144

    3. Infarct tolerance induced by repetitive cortical spreading depression is reproduced by prolonged intracerebral infusion of recombinant brain-derived neurotrophic factor

      • Hiroji Yanamoto, Jing-Hui Xue, Izumi Nagata, Nobuo Hashimoto, Masahiro Sakata, Ikuko Mizuta et al.
      Pages 145-167

  6. Strategies using hypothermia

    1. Front Matter

      Pages 169-169
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    2. The importance of thermal changes in the pathophysiology of stroke: post-stroke fever and hypothermia therapy

      • Hiroaki Naritomi, Kazuyuki Nagatsuka, Kotaro Miyashita, Hiroshi Oe, Hiroshi Moriwaki, Zhen He et al.
      Pages 171-185

    3. Cerebrovascular disease and hypothermia Part I: effects of mild hypothermia in the management of cerebrovascular disease

      • Nobuyuki Yasui, Shingo Kawamura, Akifumi Suzuki, Hiromu Hadeishi, Jun Hatazawa
      Pages 186-194

    4. Cerebrovascular disease and hypothermia Part II: an experimental approach for ischemic neuronal death

      • Yasuji Yoshida, Octavio J. Arroyo, Carlos A. Arellanes, Nobuyuki Yasui
      Pages 195-201

    5. Neuroprotection by mild hypothermia for temporary or permanent focal ischemia

      • Hiroji Yanamoto, Izumi Nagata, Hideki Sakai, Yoichi Niitsu, Zhiwen Zhang, Jing-Hui Xue et al.
      Pages 202-220
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Keywords

About this book

The importance of the therapeutic time window for ischemic stroke has been widely accepted for a long time. Consequently, I have been thinking about the past, when the term "brain attack," which was reimported from the United States, began to spread by repetition. In the 1980s, I had made an enthusiastic study of acute-phase cerebral revascularization for ischemic stroke. At that time, we could cure only a quite lim­ ited number of patients, such as those who already were hospitalized or who, fortu­ nately, were brought to the hospital within a few hours from the onset of the stroke. RM Crowell, in his 1977 report! on cases of failure, had identified the consider­ able problems in acute-phase cerebral revascularization as diagnosis of tissue reversibility, brain-protective reagents or methods, and effective techniques for revascularization. I remember that we strongly endorsed his opinion. Recently, the basic study of stroke has advanced significantly, resulting in newly developed materials and new experimental techniques, which are introduced in this book. I hope that new basic knowledge will be clinically applied.

Editors and Affiliations

  • National Cardio-Vascular Center, Suita, Osaka, Japan

    Haruhiko Kikuchi

Bibliographic Information

  • Book Title: Strategic Medical Science Against Brain Attack

  • Editors: Haruhiko Kikuchi

  • DOI: https://doi.org/10.1007/978-4-431-68430-5

  • Publisher: Springer Tokyo

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Tokyo 2002

  • Hardcover ISBN: 978-4-431-70337-2Published: 01 May 2002

  • Softcover ISBN: 978-4-431-68432-9Published: 01 March 2012

  • eBook ISBN: 978-4-431-68430-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 294

  • Topics: Neurology

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