Role of Blood Flow in Atherogenesis

1. Front Matter

   Pages I-XV

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2. Fundamental Observations on Human and Animal Atherosclerosis

   1. Front Matter

      Pages 1-1

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   2. Establishing the Hemodynamic Determinants of Human Plaque Configuration, Composition and Complication

      • S. Glagov, C. K. Zarins, D. P. Giddens, D. N. Ku

      Pages 3-10

   3. Distribution and Endothelial Morphology of Atherosclerotic Lesions at Bifurcations and Curves of Human Cerebral Arteries

      • N. Sakata, T. Fukushima, S. Takebayashi, T. Homma

      Pages 11-18

   4. Observations on Carotid Bifurcation Atherosclerosis in Human Cadavers

      • M. Kashihara, K. Matsumoto, J. CervóS-Navarro

      Pages 19-23

   5. Localization of Lipids and Cell Population in Atheromatous Lesions in Aorta and Its Main Arterial Branches in Patients with Hypercholesterolemia

      • C. Yutani, M. Imakita, H. Ishibashi-Ueda, A. Yamamoto, S. Takaichi

      Pages 25-31

   6. Underlying Morphological Changes in the Arterial Wall at Bifurcations for Atherogenesis

      • Y. Yoshida, T. Oyama, S. Wang, T. Yamane, M. Mitsumata, T. Yamaguchi et al.

      Pages 33-40

   7. The Relationship Between Intimal Thickening and the Hemodynamic Environment of the Arterial Wall

      • M. H. Friedman

      Pages 41-46

   8. The Role of Haemodynamics in the Proliferative Lesions of Atherosclerosis

      • W. E. Stehbens

      Pages 47-53

   9. Secondary Flow and Atherogenesis

      • N. Ohyama, A. Nishiyama, T. Okamura

      Pages 55-59

3. Fluid Mechanics of Blood Flow in Atherogenesis

   1. Front Matter

      Pages 61-61

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   2. The Utility of Correlations Between Model Flow Studies and Vessel Pathology in Describing Atherogenesis

      • D. P. Giddens, C. K. Zarins, D. N. Ku, S. Glagov

      Pages 63-65

   3. Flow Patterns and Preferred Sites of Atherosclerosis in Human Coronary and Cerebral Arteries

      • T. Karino, T. Asakura, S. Mabuchi

      Pages 67-72

   4. Early Atherosclerosis and Pulsatile Flow in the Human Carotid Bifurcation

      • D. N. Ku, C. K. Zarins, D. P. Giddens, S. Glagov

      Pages 73-79

   5. Flow Separation and Horseshoe Vortex in a Tube with Side Branches During Pulsatile Flow

      • T. Fukushima, T. Homma, K. Harakawa

      Pages 81-90

   6. Flow Studies in True-to-Scale Models of Human Renal Arteries

      • D. Liepsch, A. Poll, S. Moravec

      Pages 91-96

   7. Unsteady, Separated Laminar Flow in Non-Uniform Vessels

      • T. J. Pedley, M. E. Ralph, O. R. Tutty

      Pages 97-102

   8. Effects of Phase Relationships on Wall Shear Stress in Curved and Straight Elastic Artery Models

      • J. M. Tarbell, M. Klanchar, A. Dutta

      Pages 103-108

   9. Wall Shear Stress Distribution Patterns in Arterial Stenosis Models Measured with an Electrochemical Technique

      • T. Yamaguchi, S. Hanai

      Pages 109-116

   10. Intraoperative Evaluation of Blood Velocity Waveforms in Different Coronary Artery Bypass Graft

       • F. Kajiya, S. Kanazawa, S. Matsuoka, Y. Ogasawara, K. Tsujioka, T. Fujiwara

       Pages 117-122

It has long been recognized that atherosclerosis tends to develop in certain areas of the artery. Blood flow is thus considered to play an important role in such development. However, the direct mechanisms of the influence of blood flow on atherosclerosis are controversial. Recently, a number of active studies in this field have been carried out around the world. This volume consists of the contributions to a symposium held on the subject and offers a report of latest findings.

• Bypass
• Lipoprotein
• arteries
• artery
• atherosclerosis
• blood
• complication
• distribution
• dynamics
• evaluation
• hypoxia
• morphology
• pathology
• population
• smooth muscle

• Department of Pathology, Yamanashi Medical College, Tamaho, Japan

  Yoji Yoshida

• Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan

  Takami Yamaguchi

• Physiological Flow Studies Unit, Imperial College, London, England

  Colin G. Caro

• Department of Pathology, University of Chicago, Chicago, USA

  Seymour Glagov

• Biomechanics Laboratory and School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, USA

  Robert M. Nerem

Policies and ethics