Neoplasms of the Liver

1. Front Matter

   Pages I-IX

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2. Basic Aspects

   1. Front Matter

      Pages 1-1

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   2. Epidemiology of Hepatocellular Carcinoma

      • Nubia Muñoz, Xavier Bosch

      Pages 3-19

   3. Hepatitis B Virus Infection and Hepatocellular Carcinoma

      • Harvey M. Lieberman, Ran Tur-Kaspa, David A. Shafritz

      Pages 21-33

   4. Hepadna Viruses and Hepatocarcinogenesis

      • Masao Omata, Osamu Yokosuka, Fumio Imazeki, Kunio Okuda

      Pages 35-45

   5. Human Hepatoma Cell Lines

      • Jennifer J. Alexander

      Pages 47-56

   6. Analysis of Proto-oncogene Expression During Liver Regeneration and Hepatocarcinogenesis

      • Nelson Fausto, Peter R. Shank

      Pages 57-70

   7. Hepatitis B Virus Infection, Its Sequelae, and Prevention in Taiwan

      • Ding-Shinn Chen

      Pages 71-80

   8. Pathology of Hepatocellular Carcinoma

      • Masamichi Kojiro, Toshiro Nakashima

      Pages 81-104

   9. Benign Tumors of the Liver

      • Zachary D. Goodman

      Pages 105-125

   10. Hepatoblastoma

       • J. Thomas Stocker, Kamal G. Ishak

       Pages 127-136

   11. Fibrolamellar Carcinoma of the Liver

       • Donald B. Rolfes

       Pages 137-142

   12. Pathology of Cholangiocarcinoma

       • Shigetaka Sugihara, Masamichi Kojiro

       Pages 143-158

   13. Malignant Mesenchymal Tumors of the Liver

       • Kamal G. Ishak

       Pages 159-176

   14. Comparative Study of the Three Nodular Lesions in Cirrhosis

       • Goroku Ohta, Yasuni Nakanuma

       Pages 177-187

   15. Hepatocellular Carcinoma in Hemochromatosis

       • Robin A. Bradbear, June W. Halliday, Mark L. Bassett, W. Graham Cooksley, Lawrie W. Powell

       Pages 189-197

   16. Clinical Manifestations and Paraneoplastic Syndromes of Hepatocellular Carcinoma

       • Michael C. Kew

       Pages 199-211

3. Clinical Aspects

   1. Front Matter

      Pages 213-213

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   2. Small Hepatocellular Carcinoma

      • Kunio Okuda, Masamichi Kojiro

      Pages 215-226

   3. Serological Tumor Markers in Hepatocellular Carcinoma

      • Norio Sawabu, Nobu Hattori

      Pages 227-237

Primary liver cancer is a rather unusual malignancy in that the incidence varies tremendously from one geographical area to another. While relatively uncom­ mon in Western countries, it is the most prevalent malignant neoplasm in Southeast Asia, South Africa, and many other regions; in all, the countries in which primary liver cancer is very prevalent account for more than two-thirds of the world's population. In China alone, approximately 100 000 people die every year from primary liver cancer, mostly hepatocellular carcinoma. The incidence is rising in some countries, especially Japan, where it has doubled among males in the past 15 years or so, a staggering and puzzling trend. Since the demonstration of an etiological relationship between hepatitis B virus infection and hepatocellular carcinoma, intensive research has been con­ ducted in an effort to elucidate the role of the virus in hepatocarcinogenesis. Though much progress has been made, a full understanding of the molecular events leading to malignant transformation of the hepatocyte will probably require many more years of rigorous investigation. Chemical carcinogens and several industrial pollutants may also be involved in the etiopathogenesis of neoplastic liver disease.

• cancer
• carcinogenesis
• carcinoma
• hepatitis
• Hepatitis B
• hepatocellular carcinoma
• liver
• liver cancer
• liver disease
• pathogenesis
• hepatology

• First Department of Medicine, Chiba University School of Medicine, Inohana, Chiba, 280, Japan

  Kunio Okuda

• Department of Hepatic Pathology, Armed Forces Institute of Pathology, USA

  Kamal G. Ishak

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