Heart Failure

1. Front Matter

   Pages II-XIV

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2. New Insights in the Pathophysiology of Heart Failure

   1. Front Matter

      Pages 1-1

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   2. Neurohormones in Advanced Heart Failure

      • Gary S. Francis

      Pages 3-23

   3. Recent Progress in Natriuretic Hormone Research

      • Hisayuki Matsuo

      Pages 25-33

   4. Cytokines and Heart Failure: Pathophysiological Roles and Therapeutic Implications

      • Akira Matsumori

      Pages 35-45

   5. Endothelium Dysfunction in Heart Failure: A Review

      • Tsutomu Imaizumi

      Pages 47-55

   6. Pathogenesis of Myocardial Injury and Cell Death in Myocarditis: Its Relation to the Fas/Fas Ligand Pathway

      • Michiaki Hiroe, Tetsuya Toyozaki

      Pages 57-69

   7. Mechanisms of Acute Cardioprotection with Ischemic Preconditioning: Protein Kinase C and Beyond

      • Karin Przyklenk

      Pages 71-79

   8. Role of NO in Myocardial Injury Induced by Oxidative Stress: Ischemia, Myocarditis, Cardiomyopathy, and Heart Failure

      • Tsunehiko Kuzuya, Masashi Nishida

      Pages 81-87

   9. Cardiac Remodeling: Role of Neovascularization in Heart Failure

      • Hiroshi Okamoto, Masashi Watanabe, Hideki Kumamoto, Satoru Chiba, Keiji Yoneya, Hisao Onozuka et al.

      Pages 89-102

3. Heart Failure and Cardiac Sudden Death

   1. Front Matter

      Pages 103-103

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   2. Long QT Syndrome as a Cause of Cardiac Sudden Death

      • Minoru Horie, Hidetada Yoshida, Hideo Otani, Tomohiko Ai, Toshihisa Nishimoto, Tetsuya Haruna et al.

      Pages 105-113

   3. ICD Therapy: Can It Prevent Sudden Death in CHF Patients?

      • Ko Takeichi, Naoki Matsuda, Hiroshi Kasanuki

      Pages 115-120

   4. Antiarrhythmic Drug Therapy for Sudden Cardiac Death in CHF Guided by the Sicilian Gambit

      • Satoshi Ogawa

      Pages 121-125

4. Medical Treatment of Heart Failure: Beyond ACE Inhibitors

   1. Front Matter

      Pages 127-127

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   2. Clinical Practice Guidelines in Heart Failure: State of the Art in the United States

      • Marvin A. Konstam, David W. Baker

      Pages 129-137

   3. Beyond ACE Inhibitors: Angiotensin II Antagonism in Heart Failure, An Emerging Role for Losartan

      • Robert Segal

      Pages 139-152

   4. Beta-blockers in Heart Failure: Where Do We Stand Today?

      • Finn Waagstein

      Pages 153-160

   5. Endothelin Antagonism in the Treatment of Heart Failure

      • Takashi Miyauchi, Yasuro Sugishita

      Pages 161-174

   6. Heart Failure: Potential Benefit of Growth Hormone Therapy

      • Luigi Saccà, Antonio Cittadini, Salvatore Longobardi, Serafino Fazio

      Pages 175-181

Remarkable progress has been made in understanding and treating heart failure. Among other developments, angiotensin-converting enzyme inhibitors and b blockers have been found to have beneficial therapeutic effects, reinforcing the view that heart failure may be both a hemodynamic and a neurohumoral disorder. The Japanese Heart Failure Society was established to curb the threat of heart failure through research, education, and clinical practice. At the Societys 2nd Annual Scientific Meeting in Sapporo, molecular biologists, physiologists, clinicians, surgeons, and researchers in related fields met to strengthen professional bonds for the ultimate goal of preventing death from heart failure. This book contains presentations from the Sapporo conference that provide new insights into heart failure in the areas of pathophysiology, cardiac sudden death, medical and surgical treatment, and promising new gene therapy.

• Angiotensin II
• Arrhythmias
• Beyond ACE Inhibitors
• Beyond Cardiac Transplantation
• Gene Therapy
• Heart Failure
• Ischemia
• Molecular Mechanism
• Sudden Death

• Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan

  Akira Kitabatake, Hiroshi Okamoto

• Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

  Shigetake Sasayama

• Coronary and Intensive Care Unit, The Cleveland Clinic Foundation, USA

  Gary S. Francis

• Department of Cardiology, Ohio State University, Cleveland, USA

  Gary S. Francis

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