Recent Advances in Coronary Circulation

1. Front Matter

   Pages I-XIV

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2. Measurement of Coronary Blood Flow and Assessment of Myocardial Perfusion

   1. Front Matter

      Pages 1-1

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   2. Evaluation of Coronary Perfusion by Positron Emission Tomography

      • James B. Bassingthwaighte, James R. Revenaugh, Andreas Deussen, Michael M. Graham, Thomas K. Lewellen, Jeanne M. Link et al.

      Pages 2-16

   3. Regional Blood Flow Measurement with Non-Radioactive Microspheres by X-ray Fluorescence Spectrometry

      • Hidezo Mori, Julien I. E. Hoffman

      Pages 17-26

   4. Optimum Use of PET and SPECT for the Detection of Coronary Artery Disease

      • Nizar A. Mullani

      Pages 27-41

   5. Abstract

      1. Uridine is a Marker of Viability in Myocardial Ischemia

         • Hiroyuki Yaoita, Alan J. Fischman, Hiroshi Ohtani, H. William Strauss, Michito Kanke, Tsukasa Asakura et al.

         Pages 42-43

3. Coronary Flow Dynamics

   1. Front Matter

      Pages 45-45

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   2. Transmural Distribution and Heterogeneity of Coronary Flow and Flow Reserve

      • Julien I. E. Hoffman, Arthur E. Flynn, Richard E. Austin, Dwain L. Coggins, Gabriel S. Aldea, Waleed K. Husseini et al.

      Pages 46-53

   3. Effect of Vasomotor Tone on Coronary Flow Impediment in Systole

      • Nico Westerhof, Pieter Sipkema, Paul Bouma

      Pages 54-59

   4. Heart Contraction and Coronary Blood Flow

      • Jos. A. E. Spaan

      Pages 60-68

   5. Blood Velocity Profiles Along Poststenotic Coronary Artery and Stenotic Intramyocardial Flow

      • Fumihiko Kajiya, Osamu Hiramatsu, Akihiro Kimura, Masami Goto, Yasuo Ogasawara, Katsuhiko Tsujioka

      Pages 69-82

   6. Morphometric Measurement of Subendocardial Vessel Dimensions in Systolic and Diastolic Arrested Rat Heart

      • Bernard I. Levy, Jane Lise Samuel, Victor E. Kotelianski, Francoise Marotte, Pierre Poitevin, Richard S. Chadwick

      Pages 83-90

   7. Evaluation of Dynamic Mechanical Properties of Coronary Arterial System Using Multi-Channel Random Noise Technique

      • Kenji Sunagawa, Yasuhiko Harasawa, Koji Todaka

      Pages 91-98

   8. Myogenic and Flow-Induced Responses in Coronary Arterioles

      • Lih Kuo, William M. Chilian, Michael J. Davis

      Pages 99-113

   9. Effects of Coronary Collateral Circulation and Outflow Pressure Elevation on Coronary Pressure-Flow Relationships in The Beating and Non-Beating States

      • Tomiyoshi Saito, Minoru Mitsugi, Shuichi Saitoh, Masahiko Sato, Yukio Maruyama

      Pages 114-122

   10. Abstract

       1. Effect of Cardiac Contraction on Regional Myocardial Blood Flow

          • Masami Goto, Arthur E. Flynn, Joseph W. Doucette, Catharina M. A. Jansen, Marjolein M. Stork, Dwain L. Coggins et al.

          Pages 123-123

       2. Variations of Blood Pooling in Coronary Vascular Beds

          • Jun Watanabe, Katsuyuki Hangai, Shoichi Satoh, Yukio Maruyama, Tamotsu Takishima

          Pages 124-124

4. Models of Coronary Circulation

   1. Front Matter

      Pages 125-125

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   2. Theoretical Relationship among Myocardial Tissue and Cavity Pressures, Contractility, and Vascular Volume Change

      • R. S. Chadwick, Cheng Dong

      Pages 126-134

   3. Concepts and Controversies in Modelling the Coronary Circulation

      • Rafael Beyar, Dan Manor, Daniel Zinemanas, Samuel Sideman

      Pages 135-149

Coronary circulation research is advancing at a rapid rate. Not only are inno­ vative techniques for studying myocardial perfusion being developed, new mechanisms related to coronary blood flow control and mechanics are also being discovered. The progress in this field justifies an update in the form of this new monograph. The book is divided into the following sections: "Measurement of Coronary Blood Flow and Assessment of Myocardial Per­ fusion" discusses advances in perfusion measurements in humans as well as nonradioactive microsphere methods. . "Coronary Flow Dynamics" elucidates the effect of heart contraction on coronary flow, perfusion, and reserve distribution as well as systolic-diastolic interaction. Models-a frequent topic of debate-are used to quantify hypotheses. "Models of Coronary Circulation" attempts to elucidate the concept of tissue pressure. "Regulatory Mechanisms of Coronary circulation and its Clinical Relevance": N u.merous mechanisms affecting coronary flow have been defined and studied at the level of isolated vessels and whole organs. The chapters in this section provide an in-depth analysis of a selection of these mechanisms and their inter­ actions. "Pathophysiology of Coronary Circulation in Ischemic Heart Disease" considers important aspects of factors which restrict perfusion of the myocardium in ischemic heart disease. An understanding these factors is of crucial importance in the management of patients. "Small Vessel Disorder in Coronary Circulation" describes circulatory flow and how it can be influenced by drugs.

• Cardiac Metabolism
• Coronary Circulation
• Coronary Hymodynamics
• Ischemic Heart Disease
• Regulation
• Small Vessel Disease
• endothelium
• pathophysiology
• physiology
• surgery
• tissue

• First Department of Internal Medicine, Fukushima Medical College, Fukushima, Japan

  Yukio Maruyama

• Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, Kurashiki, Japan

  Fumihiko Kajiya

• Cardiovascular Research Institute, University of California, San Francisco, USA

  Julien I. E. Hoffman

• University of Amsterdam, Amsterdam, The Netherlands

  Jos A. E. Spaan

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