New Aspects in the Treatment of Failing Heart

1. Front Matter

   Pages I-XIV

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2. Ischemic Myocardial Damage

   1. Front Matter

      Pages 1-1

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   2. Postischemic Myocardial Dysfunction (Myocardial “Stunning”): Role of Oxidative Stress

      • Xiao-Ying Li, Marcel E. Zughaib, Mohamed O. Jeroudi, Craig Hartley, Jian-Zhong Sun, Selim Sekili et al.

      Pages 3-7

   3. Degradation of Membrane Phospholipids in the Ischemic and Reperfused Heart

      • Ger J. van der Vusse, Robert S. Reneman

      Pages 8-12

   4. Protective Effects of Antiarrhythmic Agents on Oxygen-Deficiency-Induced Contractile Dysfunction of Isolated Perfused Hearts

      • Satoshi Takeo, Kouichi Tanonaka, Jian-xun Liu, Yasutami Ohtsuka

      Pages 13-17

   5. Ischemic Myocardial Damage

      • Kazuo Ichihara

      Pages 18-22

3. Cardiomyopathy

   1. Front Matter

      Pages 23-23

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   2. Role of Protein Kinase System in the Signal Transduction of Stretch-mediated Myocyte Growth

      • Yoshio Yazaki, Issei Komuro

      Pages 25-29

   3. Cellular Mechanisms of Left Ventricular Hypertrophy

      • Christophe Leclercq, Jean-Marie Moalic, Daniéle Charlemagne, Pascale Mansier, Claude Sainte-Beuve, Francoise Rannou et al.

      Pages 30-35

   4. PI Response and Calcium Overload in Cardiomyopathic Hamster Heart Cell

      • Hideaki Kawaguchi, Mikako Shoki, Hitoshi Sano, Toshiyuki Kudo, Hirofumi Sawa, Hiroshi Okamoto et al.

      Pages 36-40

   5. Mitochondrial DNA Mutations in Cardiomyopathy

      • Takayuki Ito, Kazuki Hattori, Toshihiro Obayashi, Masashi Tanaka, Satoru Sugiyama, Takayuki Ozawa

      Pages 41-45

   6. Disrupted Microtubule Structure in the Ischemic and Failing Myocardium — The Role of Calcium Overload

      • Masatsugu Hori, Hiroshi Sato, Kunimitsu Iwai, Seiji Takashima, Noritake Hoki, Masatake Fukunami et al.

      Pages 46-50

4. Signal Transduction in Myocardial Cells

   1. Front Matter

      Pages 51-51

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   2. GTP-binding Proteins and Bacterial Toxin-catalyzed ADP-ribosylation

      • Toshiaki Katada, Yoshiharu Ohoka, Katsunobu Takahashi, Taroh Iiri

      Pages 53-57

   3. Regulation of the Gs Protein in the Heart

      • Paul Insel, Kazushi Urasawa, Denis Leiber, David Roth, H. Kirk Hammond

      Pages 58-61

   4. Alterations in α-Adrenergic Receptors in Response to Myocardial Ischemia and their Role in Arrhythmogenesis

      • Peter B. Corr, Thomas Kurz, Kathryn A. Yamada

      Pages 62-69

   5. Enzyme-Specific Desensitization of Adenylyl Cyclase in Hypertrophied Heart in Monocrotaline-Treated Rats

      • Katsuyuki Tobise, Hiromitsu Yoshie, Kazumi Uekita, Masaaki Fujita, Sokichi Onodera

      Pages 70-74

   6. A Mechanism of Catecholamine Tolerance In Congestive Heart Failure

      • Kazushi Urasawa, Katsuhiko Sato, Yasumi Igarashi, Hideaki Kawaguchi, Hisakazu Yasuda

      Pages 75-78

5. Electrophysiological Abnormalities in Failing Heart

   1. Front Matter

      Pages 79-79

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   2. Regulation of Calcium Slow Channels in Myocardial Cells by Cyclic Nucleotides and Phosphorylation

      • Nicholas Sperelakis, Noritsugu Tohse, Hiroshi Masuda, János Mészáros

      Pages 81-92

Molecular biology and biochemical techniques, the avant-garde of medical research, are now also being used to investigate cardiovascular events. The fifty-one selected contributions in this volume based on the 14th International Society of Heart Research (ISHR) Meeting in 1992 document the discoveries being made at the frontiers of research with cardiac molecular and genetic biology and technology. The contents may be divided into five categories: 1) the process of ischemic myocardial damage in heart failure, 2) biochemical abnormalities in cardiomyopathy, 3) signal transduction in diseased myocardial cells, 4) electrophysiological abnormalities of the failing heart, and 5) recent concepts in drug therapy. The book builds a bridge for the flow of up-to-date information from active veteran researchers to young talented investigators who offer great promise for the future.

• Angiotensin II
• angina pectoris
• arrhythmia
• cardiovascular
• cardiovascular system
• drugs
• heart
• heart disease
• heart failure
• heart rate
• hemodynamics

• Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan

  Hisakazu Yasuda, Hideaki Kawaguchi

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